Results 211 to 220 of about 1,271,098 (314)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Spatial artifact detection improves the reproducibility of drug screening experiments. [PDF]

iScience
Ianevski A, Nader K, Potdar S, Gorbonos A, Ianevski F, Tanoli Z, Saarela J, Aittokallio T.   +7 more
europepmc   +1 more source

Molecular Selection of Patients for First-Line Treatment of Advanced Non–Small-Cell Lung Cancer With Epidermal Growth Factor Inhibitors: Not Quite Ready for Prime Time [PDF]

, 2008
Frances A. Shepherd
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Inactivated Avian Infectious Bronchitis Virus Strains M41 and 4-91 Provide Broad Protection Against Multiple Avian Infectious Bronchitis Strains. [PDF]

Vaccines (Basel)
van de Weem NMP, Walczak M, van Rooij L, Hormes FAJ, Hesseling P, Timmers L, Wouters PAWM, Raue R.   +7 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Investigating and correcting a rare pathogenic mutation in GDF11. [PDF]

HGG Adv
Congdon ST, Bennett J, Opinya R, Agosto AR, Dossias O, Kokko C, Levesque AA, Koob AO, Silver AC, Thomas-Charles CA.   +9 more
europepmc   +1 more source

On the Number of Restricted Prime Factors of an Integer II [PDF]

, 2016
Alexander P. Mangerel
openalex   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Association of Preoperative Leukocyte-to-Albumin Ratio with Short- and Long-Term Outcomes After Valvular Heart Surgery: A Retrospective Cohort Study. [PDF]

J Inflamm Res
Lin Y, Liao X, Li S, Yan X, Chen L, Lin Y.   +5 more
europepmc   +1 more source