Results 51 to 60 of about 216,097 (247)
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Journal of Pure and Applied Algebra, 1993 Let \(P(n)\) be the largest prime factor of an integer \(n\), \(L(n)\) the number of \(k\leq n\) such that \(P(k)
openaire +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Toxins, 2018 Ochratoxin A (OTA) is a toxic secondary metabolite produced by several fungal species of the genus Penicillium and Aspergillus. 2′R-Ochratoxin A (2′R-OTA) is a thermal isomerization product of OTA formed during food processing at high ...
Franziska Sueck +8 more
doaj +1 more source
ON A CONJECTURE ON SHIFTED PRIMES WITH LARGE PRIME FACTORS, II
Bulletin of the Australian Mathematical Society, 2023 AbstractLet $\mathcal {P}$ be the set of primes and $\pi (x)$ the number of primes not exceeding x. Let $P^+(n)$ be the largest prime factor of n, with the convention $P^+(1)=1$ , and $ T_c(x)=\#\{p\le x:p\in \mathcal {P},P^+(p-1)\ge p^c\}. $ Motivated by a conjecture of Chen and Chen [‘On the largest prime factor of shifted primes’, Acta Math.
openaire +5 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
On the Diophantine equation Ax2+22m=yn
International Journal of Mathematics and Mathematical Sciences, 2001 Let h denote the class number of the quadratic field ℚ(−A) for a square free odd integer A>1, and suppose that n>2 is an odd integer with (n,h)=1 and m>1.
Fadwa S. Abu Muriefah
doaj +1 more source
Scheme of extending elliptic curve method to three phases
网络与信息安全学报, 2018 Elliptic curve method for integer factorization (ECM) is one of the most popular integer factorization algorithms,and it was firstly proposed by Lenstra in 1985.The original ECM contained just first phase.Since its invention,researches about the ...
Guiwen LUO
doaj +3 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source