Results 91 to 100 of about 312,664 (251)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Symmetric Bipartite Graphs of Prime Valency
European Journal of Combinatorics, 1990 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Cayley graphs of order kp are hamiltonian for k < 48
, 2018 We provide a computer-assisted proof that if G is any finite group of order kp, where k < 48 and p is prime, then every connected Cayley graph on G is hamiltonian (unless kp = 2).
Morris, Dave Witte, Wilk, Kirsten
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
SOME CHEMICAL TOPOLOGICAL INDICES FOR THE COPRIME GRAPH OF THE INTEGERS MODULO GROUP
BarekengThis paper delves into the exploration of the coprime graph of a finite group G, a graph with vertices representing all group elements. Vertices x and y are considered adjacent in ΓG if their orders are relatively prime.
Gustina Elfiyanti +4 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
THE TRIPLE IDENTITY GRAPH OF THE RING Z_n
BarekengLet be a commutative ring with identity and is an identity element of . The triple identity graph of the ring , represented by ), is an undirected simple graph with the vertex set .
Vika Yugi Kurniawan +2 more
doaj +1 more source
On some aspects of the generalized Petersen graph
Electronic Journal of Graph Theory and Applications, 2017 Let $p \ge 3$ be a positive integer and let $k \in {1, 2, ..., p-1} \ \lfloor p/2 \rfloor$. The generalized Petersen graph GP(p,k) has its vertex and edge set as $V(GP(p, k)) = \{u_i : i \in Zp\} \cup \{u_i^\prime : i \in Z_p\}$ and $E(GP(p, k)) = \{u_i ...
V. Yegnanarayanan
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source