Results 71 to 80 of about 1,036,687 (287)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
On the subsequence of primes having prime subscripts [PDF]
, 2009 We explore the subsequence of primes with prime subscripts, (qn), and derive its density and estimates for its counting function. We obtain bounds for the weighted gaps between elements of the subsequence and show that for every positive integer m there ...
Barnett, A. Ross, Broughan, Kevin A.
core
On the Symmetry Graph of Prime Numbers
, 2021 See the abstract in the attached pdf.
openaire +3 more sources
Complement of the generalized total graph of fields
AKCE International Journal of Graphs and Combinatorics, 2020 Let R be a commutative ring and H be a multiplicative prime subset of R. The generalized total graph is the undirected simple graph with vertex set R and two distinct vertices x and y are adjacent if For a field F, is the only multiplicative prime subset
T. Tamizh Chelvam, M. Balamurugan
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Extending Undirected Graph Techniques to Directed Graphs via Category Theory
MathematicsWe use Category Theory to construct a ‘bridge’ relating directed graphs with undirected graphs, such that the notion of direction is preserved. Specifically, we provide an isomorphism between the category of simple directed graphs and a category we call ‘
Sebastian Pardo-Guerra +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Characterization of rings with planar, toroidal or projective planar prime ideal sum graphs
AKCE International Journal of Graphs and CombinatoricsLet R be a commutative ring with unity. The prime ideal sum graph [Formula: see text] of the ring R is the simple undirected graph whose vertex set is the set of all nonzero proper ideals of R and two distinct vertices I and J are adjacent if and only if
Praveen Mathil +3 more
doaj +1 more source
Mathematics, 2019 In this paper, we investigate the graph structures on hoop algebras. First, by using the quasi-filters and r-prime (one-prime) filters, we construct an implicative graph and show that it is connected and under which conditions it is a star or tree.
Mona Aaly Kologani +2 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source