Results 171 to 180 of about 312,664 (251)

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

MODOMICS: a database of RNA modifications and related information. 2025 update and 20th anniversary. [PDF]

Nucleic Acids Res
Sordyl D, Boileau E, Bernat A, Maiti S, Mukherjee S, Moafinejad SN, Farsani MA, Shavina A, Cappannini A, Agostini G, Conticello SG, Stefaniak F, Dieterich C, Purta E, Bujnicki JM.   +14 more
europepmc   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

STAHD: a scalable and accurate method to detect spatial domains in high-resolution spatial transcriptomics data. [PDF]

Bioinformatics
Du Z, Wang D, Chen Q, Ou Y, Huang X, Zhou X, Zheng X.   +6 more
europepmc   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Structural analyses and substrate profiling of PPEP-3 provide new insights into the molecular basis of Pro-Pro endopeptidase specificity. [PDF]

iScience
Claushuis B, Wojtalla F, Papenhagen L, Cordfunke RA, de Ru AH, van Leeuwen HC, Corver J, Hensbergen PJ, Baumann U.   +8 more
europepmc   +1 more source

Bio‐Friendly Artificial Muscles Based on Carbon Nanotube Yarns and Eutectogel Derivatives

Advanced Functional Materials, EarlyView.
Solid‐state artificial muscles based on coiled commercial carbon nanotube yarns coated with eutectogel derivatives exhibit unipolar actuation through selective ion intercalation. Combining polyanionic and polycationic gels enables enhanced contractile stroke and high energy density.
Gabriela Ananieva, Cédric Vancaeyzeele, Giao T.M. Nguyen, Daniel Aguilera‐Bulla, Mathieu Pinault, Frédéric Vidal, Cédric Plesse   +6 more
wiley   +1 more source

Subcutaneous administration of the malaria R21/Matrix M vaccine and immune complex formation with anti-circumsporozoite protein mAb 2A10 elicit protective efficacy in mice. [PDF]

Front Immunol
Mukhopadhyay E, Camacho CL, Hill AVS, Salman AM.   +3 more
europepmc   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Adenoviral vector oropharyngeal spray immunization elicits mucosal immunity and protects against heterologous SARS-CoV-2 infection. [PDF]

NPJ Vaccines
Koopman G, Mooij P, Gaudino M, Acar RF, Irrgang P, Russ A, Blankenstein D, Fagrouch Z, Mortier D, Böszörményi KP, Remarque EJ, Bogers WM, Verschoor EJ, Gramberg T, Tenbusch M.   +14 more
europepmc   +1 more source