Results 61 to 70 of about 374,945 (254)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
On the Coprime Labelings of Hypergraph
Graph labeling is the assignment of integers to the vertices, edges, or both, subject to certain conditions. Accordingly, hypergraph labeling is also the assignment of integers to the vertices, edges, or both, subject to certain conditions. This paper is
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
National Implementation Plan for the UN Decade of Ocean Science
, 2022 The UN General Assembly took the decision on the UN Decade of Ocean Science for Sustainable Development 2021–2030 in 2017. The aim is to support marine research in the implementation of the Sustainable Development Goals.
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Strong labelings of linear forests [PDF]
, 2009 A (p, q)-graph G is called super edge-magic if there exists a bijective function f : V (G) ∪ E(G) → {1, 2, . . . , p+q} such that f(u)+f(v)+f(uv) is a constant for each uv ∈ E(G) and f(V (G)) = {1, 2, . . . , p}.
Miquel Rius-Font +7 more
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, 2021 Vaso Prime RX supplement has helped ensure that the client accomplishes appropriate sustenance. A well-being item can be utilized by guys to ensure that they perform appropriately in bed.
Vaso Prime RX
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Elegant vertex labelings with prime numbers
, 2019 We consider graph labelings with an assignment of odd prime numbers tothe vertices. Similarly to graceful graphs, a labeling is said to be elegant if theabsolute differences between the labels of adjacent vertices describe exactly thefirst even numbers ...
Gensane, Thierry
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Production of Tissue-Engineered Skin Substitutes for Clinical Applications: Elimination of Serum. [PDF]
Int J Mol Sci, 2023 Doucet EJ +8 more
europepmc +1 more source