Results 231 to 240 of about 144,627 (278)

Genetic and Pathogenic Characteristics of an Emerging Lineage 7 PRRSV-2 (Prime Pac-Like) Strain in China. [PDF]

Transbound Emerg Dis
Yang Y, Chen H, Xie F, Li X, Lan X, Wang H, Wang Z, Fan K, Wei W, Luo C, Dai A, Li X, Luo M, Wei C, Liu J.   +14 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Durable humoral immunity and long-term protection induced by a Crimean-Congo hemorrhagic fever virus replicon particle vaccine in mice. [PDF]

NPJ Vaccines
Sorvillo TE, Karaaslan E, Davies KA, Welch SR, Scholte FEM, Coleman-McCray JD, Aida-Ficken V, Pegan SD, Bergeron É, Montgomery JM, Spiropoulou CF, Spengler JR.   +11 more
europepmc   +1 more source

Finding Prime Numbers: Miller Rabin and Beyond

, 2007
Christina McIntosh
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Structural analyses and substrate profiling of PPEP-3 provide new insights into the molecular basis of Pro-Pro endopeptidase specificity. [PDF]

iScience
Claushuis B, Wojtalla F, Papenhagen L, Cordfunke RA, de Ru AH, van Leeuwen HC, Corver J, Hensbergen PJ, Baumann U.   +8 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

A multi-antigen-based SARS-CoV-2 vaccine provides higher immune responses and protection against SARS-CoV-2 variants. [PDF]

NPJ Vaccines
Alhashimi M, Sayedahmed EE, Elkashif A, Chothe SK, Wang WC, Murala MST, Gairola V, Wakamatsu N, Gontu A, Ramasamy S, LaBella L, Jakka P, Nair MS, Nissly RH, Kuchipudi SV, Mittal SK.   +15 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

A design of multiple color image encryption scheme based on finite algebraic structures. [PDF]

Sci Rep
Qayyum T, Shah T, Khan I, Popa IL.
europepmc   +1 more source