Results 51 to 60 of about 39,700 (212)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Probing R-parity violation in B-meson decays to a baryon and a light neutralino

Journal of High Energy Physics, 2023
We propose a search for B meson decays to a baryon plus missing energy at the Belle II experiment to probe supersymmetry with a GeV-scale lightest neutralino χ ~ 1 0 $$ {\overset{\sim }{\chi}}_1^0 $$ and R-parity violation (RPV).
Claudio O. Dib, Juan Carlos Helo, Valery E. Lyubovitskij, Nicolás A. Neill, Abner Soffer, Zeren Simon Wang   +5 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

An extension theorem for sober spaces and the Goldman topology

International Journal of Mathematics and Mathematical Sciences, 2003
Goldman points of a topological space are defined in order to extend the notion of prime G-ideals of a ring. We associate to any topological space a new topology called Goldman topology. For sober spaces, we prove an extension theorem of continuous maps.
Ezzeddine Bouacida, Othman Echi, Gabriel Picavet, Ezzeddine Salhi   +3 more
doaj   +1 more source

On the Sets of Real Numbers Recognized by Finite Automata in Multiple Bases [PDF]

Logical Methods in Computer Science, 2010
This article studies the expressive power of finite automata recognizing sets of real numbers encoded in positional notation. We consider Muller automata as well as the restricted class of weak deterministic automata, used as symbolic set representations
Bernard Boigelot, Julien Brusten, Veronique Bruyere   +2 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Positive solutions of a second-order nonlinear Robin problem involving the first-order derivative

Advances in Difference Equations, 2021
This paper is concerned with the second-order nonlinear Robin problem involving the first-order derivative: { u ″ + f ( t , u , u ′ ) = 0 , u ( 0 ) = u ′ ( 1 ) − α u ( 1 ) = 0 , $$ \textstyle\begin{cases} u''+f(t,u,u^{\prime })=0, \\ u(0)=u'(1)-\alpha u ...
Zhilin Yang
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Unconscious Presentation of Object Affordances Evokes a Negative Compatibility Effect [PDF]

i-Perception, 2014
According to Gibson's (1979) theory of “affordances”, the environment is constantly bombarding the viewer with a multitude of possible actions. More recently, it has been suggested that the simple viewing of an object can automatically elicit motor plans
S Makris, K Yarrow
doaj   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source