Results 61 to 70 of about 1,016,756 (235)

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Positive solutions of a second-order nonlinear Robin problem involving the first-order derivative

Advances in Difference Equations, 2021
This paper is concerned with the second-order nonlinear Robin problem involving the first-order derivative: { u ″ + f ( t , u , u ′ ) = 0 , u ( 0 ) = u ′ ( 1 ) − α u ( 1 ) = 0 , $$ \textstyle\begin{cases} u''+f(t,u,u^{\prime })=0, \\ u(0)=u'(1)-\alpha u ...
Zhilin Yang
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Dual Mechanism Priming Effects in Hindi Word Order [PDF]

arXiv, 2022
Word order choices during sentence production can be primed by preceding sentences. In this work, we test the DUAL MECHANISM hypothesis that priming is driven by multiple different sources. Using a Hindi corpus of text productions, we model lexical priming with an n-gram cache model and we capture more abstract syntactic priming with an adaptive neural
arxiv  

Unconscious Presentation of Object Affordances Evokes a Negative Compatibility Effect [PDF]

i-Perception, 2014
According to Gibson's (1979) theory of “affordances”, the environment is constantly bombarding the viewer with a multitude of possible actions. More recently, it has been suggested that the simple viewing of an object can automatically elicit motor plans
S Makris, K Yarrow
doaj   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Molecular Topology Index of a Zero Divisor Graph on a Ring of Integers Modulo Prime Power Order

Contemporary Mathematics and Applications (ConMathA)
In chemistry, graph theory has been widely utilized to address molecular problems, with numerous applications in graph theory and ring theory within this field.
Didit Satriawan, Qurratul Aini, Abdurahim, Fariz Maulana, I Gede Adhitya Wisnu Wardhana   +4 more
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

On the appearance of primes in linear recursive sequences

Advances in Difference Equations, 2005
We present an application of difference equations to number theory by considering the set of linear second-order recursive relations, Un+2(R,Q)=RUn+1−QUn, U0=0, U1=1, and Vn+2(R,Q)=RVn+1−QVn, V0=2,  V1=R, where R and Q are relatively ...
John H. Jaroma
doaj   +1 more source