Results 71 to 80 of about 1,016,756 (235)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Automorphisms of Regular Wreath Product 𝑝-Groups
International Journal of Mathematics and Mathematical Sciences, 2009 We present a useful new characterization of the automorphisms of the regular wreath product group 𝑃 of a finite cyclic 𝑝-group by a finite cyclic 𝑝-group, for any prime 𝑝, and we discuss an application.
Jeffrey M. Riedl
doaj +1 more source
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Wolstenholme and Morley, Primes and Pseudoprimes [PDF]
arXiv, 2013 In this note, we prove $p^2$ is a Morley pseudoprime (of order 2) iff $p^2$ is a Wolstenholme pseudoprime (of order 2) iff $p$ is a Wolstenholme prime iff $p$ is a Morley prime. Concerning pseudoprimes of order 1 that are not powers of primes, only 3 are known of Wolstenholme's type and absolutely none have yet been identified of Morley's type.
arxiv
W ± Z production at NNLO QCD and NLO EW matched to parton showers with MiNNLOPS
Journal of High Energy Physics, 2022 We consider W ± Z production in hadronic collisions and present high-precision predictions in QCD and electroweak (EW) perturbation theory matched to parton showers.
Jonas M. Lindert +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Moufang Twin Trees of prime order [PDF]
arXiv, 2016 We prove that the unipotent horocyclic group of a Moufang twin tree of prime order is nilpotent of class at most 2.
arxiv
FEBS Open Bio, EarlyView.The thermophilic acetogenic model organism Moorella thermoacetica can utilize lactate as substrate. The formation of lactate by reduction of pyruvate is energetically favorable, but the reverse reaction, the oxidation of lactate to pyruvate with NAD+ as electron acceptor is challenging.
Florian P. Rosenbaum, Volker Müller
wiley +1 more source
Medial quasigroups of prime square order [PDF]
arXiv, 2016 We prove that, for any prime $p$, there are precisely $2p^4-p^3-p^2-3p-1$ medial quasigroups of order $p^2$, up to isomorphism.
arxiv
FEBS Open Bio, EarlyView.IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He +5 more
wiley +1 more source