Results 71 to 80 of about 967,837 (257)

A class of singular n-dimensional impulsive Neumann systems

Advances in Difference Equations, 2018
This paper investigates the existence of infinitely many positive solutions for the second-order n-dimensional impulsive singular Neumann system −x″(t)+Mx(t)=λg(t)f(t,x(t)),t∈J,t≠tk,−Δx′|t=tk=μIk(tk,x(tk)),k=1,2,…,m,x′(0)=x′(1)=0.
Ping Li, Meiqiang Feng, Minmin Wang
doaj   +1 more source

Positive solutions of a second-order nonlinear Robin problem involving the first-order derivative

Advances in Difference Equations, 2021
This paper is concerned with the second-order nonlinear Robin problem involving the first-order derivative: { u ″ + f ( t , u , u ′ ) = 0 , u ( 0 ) = u ′ ( 1 ) − α u ( 1 ) = 0 , $$ \textstyle\begin{cases} u''+f(t,u,u^{\prime })=0, \\ u(0)=u'(1)-\alpha u ...
Zhilin Yang
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Unconscious Presentation of Object Affordances Evokes a Negative Compatibility Effect [PDF]

i-Perception, 2014
According to Gibson's (1979) theory of “affordances”, the environment is constantly bombarding the viewer with a multitude of possible actions. More recently, it has been suggested that the simple viewing of an object can automatically elicit motor plans
S Makris, K Yarrow
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

An extension theorem for sober spaces and the Goldman topology

International Journal of Mathematics and Mathematical Sciences, 2003
Goldman points of a topological space are defined in order to extend the notion of prime G-ideals of a ring. We associate to any topological space a new topology called Goldman topology. For sober spaces, we prove an extension theorem of continuous maps.
Ezzeddine Bouacida, Othman Echi, Gabriel Picavet, Ezzeddine Salhi   +3 more
doaj   +1 more source

Probing R-parity violation in B-meson decays to a baryon and a light neutralino

Journal of High Energy Physics, 2023
We propose a search for B meson decays to a baryon plus missing energy at the Belle II experiment to probe supersymmetry with a GeV-scale lightest neutralino χ ~ 1 0 $$ {\overset{\sim }{\chi}}_1^0 $$ and R-parity violation (RPV).
Claudio O. Dib, Juan Carlos Helo, Valery E. Lyubovitskij, Nicolás A. Neill, Abner Soffer, Zeren Simon Wang   +5 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source