Results 91 to 100 of about 1,840,438 (303)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Molecular Topology Index of a Zero Divisor Graph on a Ring of Integers Modulo Prime Power Order

Contemporary Mathematics and Applications (ConMathA)
In chemistry, graph theory has been widely utilized to address molecular problems, with numerous applications in graph theory and ring theory within this field.
Didit Satriawan, Qurratul Aini, Abdurahim, Fariz Maulana, I Gede Adhitya Wisnu Wardhana   +4 more
doaj   +1 more source

On the appearance of primes in linear recursive sequences

Advances in Difference Equations, 2005
We present an application of difference equations to number theory by considering the set of linear second-order recursive relations, Un+2(R,Q)=RUn+1−QUn, U0=0, U1=1, and Vn+2(R,Q)=RVn+1−QVn, V0=2,  V1=R, where R and Q are relatively ...
John H. Jaroma
doaj   +1 more source

Uncertainties inherent in the decomposition of a Transformation

, 2008
This contribution adds to the points on the made by De Abreu and Guerra. We show that the Lorentz Transformation can be composed by the physical observations made in a frame K of events in a frame K-prime viz i) objects in K-prime are moving at a speed ...
Chandru Iyer, de Abreu R, Macdonald A, Martinez A, Martinez A, Reichenbach H   +5 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Automorphisms of Regular Wreath Product 𝑝-Groups

International Journal of Mathematics and Mathematical Sciences, 2009
We present a useful new characterization of the automorphisms of the regular wreath product group 𝑃 of a finite cyclic 𝑝-group by a finite cyclic 𝑝-group, for any prime 𝑝, and we discuss an application.
Jeffrey M. Riedl
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source