Results 71 to 80 of about 204,704 (282)
A Generalization of Source of Semiprimeness
Journal of New TheoryThis paper characterizes the semigroup ideal $\mathcal{L}_{R}^{n}(I)$ of a ring $R$, where $I$ is an ideal of $R$, defined by $\mathcal{L}_{R}^{0}(I)=I$ and $\mathcal{L}_{R}^{n}(I)=\{a\in R \mid aRa\subseteq \mathcal{L}_{R}^{n-1}(I)\}$, for all $n\in ...
Çetin Camcı +3 more
doaj +1 more source
On commutativity of prime and semiprime rings with generalized derivations
Ratio Mathematica, 2020 Let $R$ be a prime ring, extended centroid $C$ and $m, n, k \geq1$ are fixed integers. If $R$ admits a generalized derivation $F$ associated with a derivation $d$ such that $(F(x)\circ y)^{m}+(x\circ d(y))^{n}=0$ or $(F(x)\circ_{m} y)^{k} + x\circ_{n} d ...
MD Hamidur Rahaman
doaj +1 more source
Open Mathematics, 2022 Generalized Munn rings exist extensively in the theory of rings. The aim of this note is to answer when a generalized Munn ring is primitive (semiprimitive, semiprime and prime, respectively).
Guo Junying, Guo Xiaojiang
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Journal of Mathematical and Fundamental Sciences, 2019 In this paper, assuming that N is a near-ring and P is an ideal of N, the P-center of N, the P-center of an element in N, the P-identities of N are defined. Their properties and relations are investigated.
Akın Osman Atagün +3 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Formal Fibers of Prime Ideals in Polynomial Rings [PDF]
, 2014 Let (R,m) be a Noetherian local domain of dimension n that is essentially finitely generated over a field and let R^ denote the m-adic completion of R.
Heinzer, William +2 more
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source