Results 81 to 90 of about 702,392 (300)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
$J$-prime ideals of commutative rings
summary:Let $R$ be a commutative ring with identity, and $J(R)$ denote the Jacobson radical of $R$. This paper introduces $J$-prime ideals, generalizing prime ideals, $n$-ideals, and $J$-ideals. A proper ideal $I$ of $R$ is a $J$-prime ideal if for every
Koç, Suat +3 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
On the Structure of Semiderivations in Prime Rings [PDF]
Proceedings of the American Mathematical Society, 1990 Let R R be a prime ring. By a semiderivation associated with a function
openaire +2 more sources
, 1975 A ring R is (right) strongly prime (SP) if every nonzero twosided ideal contains a finite set whose right annihilator is zero. Examples are domains, prime Goldie rings and simple rings; however, this notion is asymmetric and a right but not left SP ring ...
David Handelman, John Lawrence
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Prime ideals in the quantum grassmanian [PDF]
, 2008 We consider quantum Schubert cells in the quantum grassmannian and give a cell decomposition of the prime spectrum via the Schubert cells. As a consequence, we show that all primes are completely prime in the generic case where the deformation parameter ...
Lenagan, T.H. +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Prime Ideals and Strongly Prime Ideals of Skew Laurent Polynomial Rings
International Journal of Mathematics and Mathematical Sciences, 2008 We first study connections between α-compatible ideals of R and related ideals of the skew Laurent polynomials ring R[x,x−1;α], where α is an automorphism of R.
E. Hashemi
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Journal of Algebra, 1980 In this note, we find similar characteristic properties in terms of certain intersections of maximal left ideals for the following classes of rings: (1) Left V-rings; (2) Left f-V-rings; (3) Left p-V-rings. The well-known characterisation of v-rings due to Villamayor is weakened.
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