Results 101 to 110 of about 17,177 (306)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Characterization of rings with planar, toroidal or projective planar prime ideal sum graphs

AKCE International Journal of Graphs and Combinatorics
Let R be a commutative ring with unity. The prime ideal sum graph [Formula: see text] of the ring R is the simple undirected graph whose vertex set is the set of all nonzero proper ideals of R and two distinct vertices I and J are adjacent if and only if
Praveen Mathil, Barkha Baloda, Jitender Kumar, A. Somasundaram   +3 more
doaj   +1 more source

On V-rings and prime rings

Journal of Algebra, 1980
In this note, we find similar characteristic properties in terms of certain intersections of maximal left ideals for the following classes of rings: (1) Left V-rings; (2) Left f-V-rings; (3) Left p-V-rings. The well-known characterisation of v-rings due to Villamayor is weakened.
openaire   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A quadratic Poisson Gel'fand-Kirillov problem in prime characteristic [PDF]

, 2015
The quadratic Poisson Gel’fand-Kirillov problem asks whether the field of fractions of a Poisson algebra is Poisson birationally equivalent to a Poisson affine space, i.e. to a polyno-mial algebra K[X1,..., Xn] with Poisson bracket defined by {Xi, Xj} =
Lecoutre, Cesar, S Launois, C Lecoutre, Launois, Stephane   +3 more
core   +1 more source

Prime Ideals and Homoderivations on Rings

Cumhuriyet Science Journal
In this paper, we aim to establish a new approach that involves characterizing the commutativity of a quotient ring L/P with homoderivations of L satisfying some algebraic identities involving the prime ideal P.
Zeliha Bedir
doaj   +1 more source

On Maps of Period 2 on Prime and Semiprime Rings

International Journal of Mathematics and Mathematical Sciences, 2014
A map f of the ring R into itself is of period 2 if f2x=x for all x∈R; involutions are much studied examples. We present some commutativity results for semiprime and prime rings with involution, and we study the existence of derivations and generalized ...
H. E. Bell, M. N. Daif
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Weak right η-centralizers of prime rings

Journal of Taibah University for Science
This work encompasses the study of certain weak maps termed as weak right η-centralizers defined on [Formula: see text] a noncommutative prime ring to [Formula: see text]. The first section provides an overview of the motivation behind our work.
Mohammad Aslam Siddeeque, Nazim Khan, Ali Ahmed Abdullah   +2 more
doaj   +1 more source