Results 61 to 70 of about 212,333 (259)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Consecutive primes in tuples [PDF]

open access: yes, 2014
In a recent advance towards the Prime $k$-tuple Conjecture, Maynard and Tao have shown that if $k$ is sufficiently large in terms of $m$, then for an admissible $k$-tuple $\mathcal{H}(x) = \{gx + h_j\}_{j=1}^k$ of linear forms in $\mathbb{Z}[x]$, the set
Banks, William D.   +2 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Counting Functions to Generate The Primes in the RSA Algorithm and Diffie-Hellman Key Exchange

open access: yesIbn Al-Haitham Journal for Pure and Applied Sciences, 2018
        The Rivest–Shamir–Adleman (RSA) and the Diffie-Hellman (DH) key exchange are famous methods for encryption. These methods  depended on selecting the primes p and q in order  to be secure enough .
Faez Ali AL-Maamori, Mazin Saied Rashid
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Impaired Early-Response Inhibition in Overweight Females with and without Binge Eating Disorder. [PDF]

open access: yesPLoS ONE, 2015
Several studies report increased reward sensitivity towards food in overweight individuals. By contrast, data is inconclusive with respect to response inhibition in overweight individuals without binge eating disorder (BED).
Jennifer Svaldi   +3 more
doaj   +1 more source

Prime languages

open access: yesInformation and Computation, 2013
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Orna Kupferman, Jonathan Mosheiff
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The flexibility of nonconsciously deployed cognitive processes: evidence from masked congruence priming. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: It is well accepted in the subliminal priming literature that task-level properties modulate nonconscious processes. For example, in tasks with a limited number of targets, subliminal priming effects are limited to primes that are physically ...
Matthew Finkbeiner, Jason Friedman
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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