The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Cognitive load impairs athletes' subliminal processing: behavioral and neural insights. [PDF]
Mao X, Chen J, Yu Y, Huang Q, Shi J.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Recognizing Plant Defense Priming.
A. Martínez‐Medina +8 more
semanticscholar +1 more source
Growth and Hormonal Responses to Salicylic Acid and Calcium Chloride Seed Priming in Domestic and Wild Salt-Tolerant Barley Species Under Saline Conditions. [PDF]
Ben Youssef R +6 more
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The effects of attachment security priming on posttraumatic appraisals among individuals with posttraumatic stress disorder. [PDF]
Hopwood S, Azevedo S, Bryant RA.
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Delonix regia pollen extract enhances growth and bioactive compound production in Coriandrum sativum by upregulating key biosynthetic genes. [PDF]
Bassiouni EM +3 more
europepmc +1 more source

