Results 211 to 220 of about 323,998 (369)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Multi-Omics Approach Reveals Interleukin 1 Beta Priming as a Key Driver of Immunomodulatory and Regenerative Programs in Adipose-Derived Stem Cells for Osteoarthritis Therapy. [PDF]

Cells
Miceli V, Ligotti ME, Raffo V, Lopa S, Ippolito V, Gallo A, Cuscino N, Scilabra SD, Lo Pinto M, Messina S, D'Arpa S, Moretti M, de Girolamo L, Bulati M, Colombini A.   +14 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Potential osmotic and hormonal priming for higher productivity of rice

, 2013
A study was conducted to evaluate the efficiency of different priming media for enhancing growth and development of MR219 rice in Malaysia. Different osmotic salts and plant hormones were used as priming media at four concentrations.
Puteh, Adam, Habib, Sheik Hasna, Kareem, Isiaka, Ismail, Mohd Razi, Kausar, Hossain, Abdul Rahim, Anuar   +5 more
core  

A neurocognitive interactive activation model of semantic priming in lexical decisions. [PDF]

Sci Rep
Sokolovič L, Kukolja J, Hofmann M.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Stimulation priming and psychological state shape functional connectivity following prefrontal theta-burst stimulation. [PDF]

Imaging Neurosci (Camb)
De Smet S, Wu GR, Klooster DCW, Catoira B, De Witte S, Razza LB, van de Ven V, Sack AT, Baeken C, Vanderhasselt MA.   +9 more
europepmc   +1 more source

Additional file 4: of Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness

, 2018
David G. Ashbrook, Benjamin Hing, Lindsay T. Michalovicz, Kimberly A. Kelly, Julie Miller, Wilfred De Vega, Diane B. Miller, Gordon Broderick, James O’Callaghan, Patrick O. McGowan   +9 more
openalex   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Masked priming across languages : an insight into bilingual lexical processing

, 2003
The masked priming paradigm appears to hold particular promise for the investigation of lexical access in bilinguals because it is possible to test participants in one language (that of the target word) and manipulate the language of the prime without ...
Sanchez-Casas, Rosa, Kim, Jeesun, Davis, Chris   +2 more
core