Results 231 to 240 of about 323,998 (369)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial topology and competitive access differentially shape early T cell priming in the lymph node: an agent-based modeling approach. [PDF]

Front Immunol
Vancells L, Green L, Kong N.
europepmc   +1 more source

Does “Ancestor” priming decrease the antisocial attitude

Yuko Shiraiwa
openalex   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Seed priming with melatonin enhances salt stress tolerance in triticale through coordinated regulation of antioxidant defense, osmotic homeostasis, and phytohormone signaling. [PDF]

BMC Plant Biol
Lu Y, Zhu L, Sun H, Zhang K, Zhang Y, Bai Z, Wang Z, Li C, Liu L.   +8 more
europepmc   +1 more source

Are stream biofilms a prime site for priming?

, 2016
Karoline Wagner
openalex   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Polyrhythms in the Brain: Metrical Priming, Acoustic Balance, and Perceptual Biases. [PDF]

Ann N Y Acad Sci
Møller C, Celma-Miralles A, Borges HB, Stupacher J, Christensen CB, Vuust P, Kidmose P.   +6 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Seed priming-induced enhancement in seed germination, Seedling vigor, and productivity of foxtail millet (Setaria italica L.) in winter and summer seasons under Bangladesh conditions. [PDF]

PLoS One
Islam AKMM, Khatun T, Bipra PC, Sazzad M, Roy TK, Rana MM, Yeasmin S, Kheya SA, Urmi SA, Meem MMM, Anwar MP, Islam AKMA.   +11 more
europepmc   +1 more source