Results 31 to 40 of about 2,679 (259)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

‘‘Thus we forever see the ages as they appear mirrored in our spirits”: Willhelm Worringer’s Abstraction and Empathy as longseller, or the birth of artistic modernism from the spirit of the imagined 0ther [PDF]

open access: yesJournal of Art Historiography, 2015
As welcome as Worringer’s plea for a global broadening of art-historical research may seem from the present perspective, his theoretical approach, which is tied to a fictive other and determined by primitivist ideas remains problematic.
Ursula Helg
doaj  

0257 A Half-Hearted Expressionist Extortion

open access: yesRIHA Journal, 2021
This article traces the genealogy of Expressionism in Uruguay as an artistic form that, within the framework of a figurative art trend of social and popular orientation, questioned the hegemonic guidelines regarding the cultural identity under ...
María Frick
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

open access: yesFEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Worlds of Freedom and Unfreedom: The Totalitarian Imaginaries of Lewis Grassic Gibbon’s Gay Hunter and Antoni Słonimski’s Two Ends of the World

open access: yesBiblos
This paper analyses the visions of totalitarian futures in two works written in the interwar period, namely Lewis Grassic Gibbon’s Gay Hunter (1934) and Antoni Słonimski’s Two Ends of the World (1937).
Katarzyna Pisarska
doaj   +1 more source

Éloge du primitivisme : d’autres visages de la peinture japonaise prémoderne

open access: yesPerspective, 2020
In the 1920s, the intellectual Yanagi Muneyoshi (1889–1961) began a rereading of the arts of Japan that would lead to a significant movement of recognition and revitalization of folk art, under the name Mingei. This article revisits Yanagi’s undertaking,
Christophe Marquet
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Archigram in Monte Carlo and the idea of equipped landscape

open access: yesMateria Arquitectura, 2011
In 1970, Archigram wins the competition for the entertainment center of Monte Carlo, Monaco. The jury’s profile could explain the sympathy for sophisticated technological solutions, the sort of response that could be expected from Archigram. And it would
Claudia Costa Cabral
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Multidimensional Properties: Primitivism vs Reductionism

open access: yesMetaphysics
The focus of this paper is on the metaphysical nature of multidimensional properties, properties like virtue, beauty, or health which can be had in different ways and to different degrees.
Robert Michels
doaj   +1 more source

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