Results 71 to 80 of about 243,889 (241)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Contractual Mechanisms in National Park Management: A Multi-Task Principal–Agent Model
LandIn the management of national parks, the principal–agent relationship is key to efficient and effective management. Based on multi-task principal–agent theory, this study examines the dual functions of central government incentives and guidance and the ...
Mingxin Lin, Zuomin Wen
doaj +1 more source
Formal and Informal Institutions in Wal-Mart Case
JPAIR, 2013 This paper analyzes the strategies which are followed by Wal-Mart in different parts of the world from the viewpoint of theories of institutions, property rights and agency.
José Vargas-hernández
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
ANALISIS FINANSIAL DAN KELEMBAGAAN RANTAI NILAI MEBEL MAHONI JEPARA
Jurnal Analisis Kebijakan Kehutanan, 2011 Industri mebel umumnya termasuk dalam industri kecil dan menengah. Selain berperan dalam penerimaan devisa, bisnis di bidang mebel ini juga menciptakan lapangan kerja bagi masyarakat terutama di Kabupaten Jepara. Adanya hubungan (pemberi kepercayaan) - (
Nunung Parlinah +2 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Study on the project supervision system based on the principal-agent theory
Journal of Industrial Engineering and Management, 2015 Purpose: In order to solve problems in the current project management system, the paper presents the asymmetric information games existing in construction projects through information economics viewpoints.Design/methodology/approach: The owner has ...
Runtong Zhang +3 more
doaj +1 more source
The effect of random shocks on reciprocal behavior in dynamic principal-agent settings. [PDF]
Exp Econ, 2023 Kerschbamer R, Oexl R.
europepmc +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Understanding Budget Reality in The Perspective of Symbolic Interactionism
International Research Journal of Business Studies, 2016 This study aims to interpret the meaning of budget on one of the StateOwned Enterprises (SOEs) to minimize conflict between principal and agent. Analysis is done using symbolic interactionism method in interpretive paradigm.
Lilis Ardini, Nurul Hasanah Uswati Dewi
doaj +1 more source