Results 41 to 50 of about 587,514 (266)

Political Decentralization and Governance in Hargaisa Local Government, Somaliland [PDF]

Applied Research in Administrative Sciences
This research aimed to reveal, through practical observation, the extent to which political decentralization can be considered a factor contributing to transparent governance in the local government of Hargaisa, Somaliland.
Mustafe Mahamoud, ABDILLAHI , Benjamin Bella, OLUKA, Joseph, TINDYEBWA   +2 more
doaj   +1 more source

Operational Risk Management of Public–Private Partnership Infrastructure Projects: A Bibliometric Literature Review

Buildings, 2022
Public–private partnerships (PPPs) are widely applied in the procurement of capital infrastructure, encompassing phases such as financing, design, construction, operation, and transfer.
Weiling Jiang, Qianying Yang, Jie Jiang, Igor Martek, Fanjie Gao   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Moral Hazard in Dynamic Risk Management [PDF]

, 2015
We consider a contracting problem in which a principal hires an agent to manage a risky project. When the agent chooses volatility components of the output process and the principal observes the output continuously, the principal can compute the ...
Cvitanić, Jakša, Possamaï, Dylan, Touzi, Nizar   +2 more
core   +5 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Optimal Incentive Mechanism: Balancing the Complex Risk Preferences of Shared Battery Swapping Station Enterprises Under Dual Asymmetric Information

World Electric Vehicle Journal
This study investigates how the government can design optimal incentive mechanisms for Shared Battery Swapping Station (SBSS) construction enterprises under the conditions of dual information asymmetry (effort and operational efficiency) and ...
Lei He, Yanfei Lan, Mingmao Hu, Aihong Gong   +3 more
doaj   +1 more source

Principle – Agent Model for Sleeping Partnership Moral hazard [PDF]

Faslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2011
Game theory has a significant role in contemporary orthodox economics. This theory studies the strategic behavior of players. So strategic interaction is the key point in the games theory.  Principalagent model is an application of the theory. This model
Mohammad Hadi Zahidi Vafa, seyyed hasan ghavami   +1 more
doaj  

Limitation of the principal-agent theory to explain the problem of non-compliance in South African municipalities

Journal of Public Administration and Development Alternatives, 2020
The obstinate problem of non-compliance with municipal finance legislation in South Africa has been largely explained as a principal-agent problem. Accordingly, the municipal officials as agents are depicted as potentially non-compliant, dishonest, and ...
T Khaile
doaj   +1 more source

The Principal-Agent Model with an Informative Signal to the Advantage of the Agent [PDF]

Problemi Ekonomiki, 2019
This article deals with the problem of negative impact of information asymmetry on the market and methods for mitigating it. This problem is solved by using the methods of the economic theory of contracts.
Nykyforchyn Iryna V.
doaj   +1 more source