Results 41 to 50 of about 8,580,336 (264)
Navigating Risk Aversion and Regret
This study investigates the distinctive modeling of regret utility when compared with common utility. I also introduce the interplay between common utility and regret utility.
Miwaka Yamashita
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Political Decentralization and Governance in Hargaisa Local Government, Somaliland [PDF]
This research aimed to reveal, through practical observation, the extent to which political decentralization can be considered a factor contributing to transparent governance in the local government of Hargaisa, Somaliland.
Mustafe Mahamoud, ABDILLAHI +2 more
doaj +1 more source
The obstinate problem of non-compliance with municipal finance legislation in South Africa has been largely explained as a principal-agent problem. Accordingly, the municipal officials as agents are depicted as potentially non-compliant, dishonest, and ...
T Khaile
doaj +1 more source
The role of the agent's outside options in principal-agent relationships [PDF]
We consider a principal-agent model of adverse selection where, in order to trade with the principal, the agent must undertake a relationship-specific investment which affects his outside option to trade, i.e.
Rasul, I., Sonderegger, S.
core
Externalities and the Allocation of Decision Rights in the Theory of the Firm [PDF]
This paper views authority as the right to undertake decisions that have external effects on other members of the organization. Because of contractual incompleteness, monetary incentives are insufficient to internalize these effects in the decision maker’
Bester, Helmut
core +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
This study investigates how the government can design optimal incentive mechanisms for Shared Battery Swapping Station (SBSS) construction enterprises under the conditions of dual information asymmetry (effort and operational efficiency) and ...
Lei He +3 more
doaj +1 more source

