Results 61 to 70 of about 587,514 (266)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Principal-agent Theory Based Risk Allocation Model for Virtual Enterprise [PDF]
, 2010 In this paper, we consider a risk analysis model for Virtual Enterprise (VE) by exploring the state of the art of the principal-agent theory. In particular, we deal with the problem of allocating the cost of risk between two parties in a VE, namely, the ...
Chen, K, Ching, WK, Huang, M, Siu, KTK
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Does Monitoring Decrease Work Effort ? The Complementarity Between Agency and Crowding-Out Theorie [PDF]
Agency theory assumes that tighter monitoring by the principal should motivate the agent to raise his effort level whereas the “crowding-out” literature suggests that it may reduce the overall work effort.
David Dickinson, Marie-Claire Villeval
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The Application of The Agency Theory In Planning And Staff Assignment of CPA Firms [PDF]
بررسیهای حسابداری و حسابرسی, 1994 This article extends the concept of agency theory to multi-objective contractual settings and operationalizes the elements of the basic agency model by applying that model to the operations of a CPA firm, and specifying the pareto-optimal contracts that ...
Dr. Mohammad Narnazi
doaj
The Crowding-Out of Work Ethics [PDF]
This paper analyses optimal contracts in a principal-agent model where the agent is intrinsically motivated at the outset and there is an endogenous relationship between the structure of incentive payments and intrinsic motivation (crowding effects). The
Grepperud, Sverre +1 more
core
The Relevance of the Principal-Agent Model for the Analysis of Public Policies : Do the Objectives Conflict ? [PDF]
, 2007 This paper aims to provide empirical support for the use of the principal-agent framework in the analysis of public sector and public policies. After reviewing the different conditions to be met for a relevant analysis of the relationship between ...
Chatagny, F., Soguel, N.
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Articulating Principals, Agents and Institutions in the EU [PDF]
Principal agent problems arise frequently in situations of interdependence. Europe, with its various arrangements, is replete with principal agent problems that are mediated by institutions at various levels.
Mark McGovern, Nurcan Temel
core