Results 61 to 70 of about 8,580,336 (264)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Deterministic versus Stochastic Mechanisms in Principal–Agent Models [PDF]
This paper shows that, contrary to what is generally believed, decreasing concavity of the agent’s utility function with respect to the screening variable is not sufficient to ensure that stochastic mechanisms are suboptimal.
Strausz, Roland
core +2 more sources
E3S Web of Conferences, 2019 Without considering the existence of third-party audit supervision and considering the existence of third-party audit supervision, the principal-agent model of major engineering audits between government and audit organizations was constructed.
Zhao Liang, Zheng Chuiyong
doaj +1 more source
Fairness and Incentives in a Multi-Task Principal-Agent Model [PDF]
This paper reports on a two-task principal-agent experiment in which only one task is contractible. The principal can either offer a piece-rate contract or a (voluntary) bonus to the agent. Bonus contracts strongly outperform piece rate contracts.
Fehr, Ernst, Schmidt, Klaus M.
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Principal-Agent Problem with Minimum Performance Insurance [PDF]
A minimum performance insurance in the Principal-Agent problem is wealth reducing to the principal. This result points to further inefficiencies in mandatory individual Pension Funds' contracts, particularly the one established in the 1993's 100th Law in
Juan Manuel Julio
core
, 2023 We introduce and study a computational version of the principal-agent problem - a classic problem in Economics that arises when a principal desires to contract an agent to carry out some task, but has incomplete information about the agent or their ...
David Hyland (21537970) +2 more
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
The Application of The Agency Theory In Planning And Staff Assignment of CPA Firms [PDF]
بررسیهای حسابداری و حسابرسی, 1994 This article extends the concept of agency theory to multi-objective contractual settings and operationalizes the elements of the basic agency model by applying that model to the operations of a CPA firm, and specifying the pareto-optimal contracts that ...
Dr. Mohammad Narnazi
doaj