Results 81 to 90 of about 8,580,336 (264)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Design a contract! : A simple principal-agent problem as a classroom experiment [PDF]
We present a simple classroom principal-agent experiment that can effectively be used as a teaching device to introduce important concepts of organizational economics and contracting.
Königstein, Manfred, Gächter, Simon
core
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
TEORI AGENCY DALAM PEMIKIRAN ORGANISASI ; PENDEKATAN POSITIVIST DAN PRINCIPLE-AGEN
Jurnal Riset Akuntansi dan Bisnis Airlangga, 2018 Agency theory has been used by researchers in accounting, economics, finance, marketing, political science, organizational behavior, and sociology. However, this theory is still surrounded by controversy.
Deddy Kurniawansyah
doaj +1 more source
Can Bayesian agents always be rational? A principled analysis of consistency of an Abstract Principal Principle [PDF]
, 2013 The paper takes the Abstract Principal Principle to be a norm demanding that subjective degrees of belief of a Bayesian agent be equal to the objective probabilities once the agent has conditionalized his subjective degrees of beliefs on the values of ...
Rédei, Miklós, Gyenis, Zalán
core
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
VOLATILITY AND WESTERN EUROPEAN PARTY SYSTEMS: TWO NEW APPROACHES
Baltic Journal of Political Science, 2015 The sharp rise in electoral volatility in the last two decades calls for a new explanation of Western European party systems. The established party system theory—Lipset and Rokkan’s “freezing hypothesis”—is not confirmed by today’s data.
Jan-Erik Lane
doaj +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Control and information in a dynamic multiple agent model. [PDF]
he controllability principle says that an individual should be rewarded on the basis of what he controls. This paper studies this principle from a principal agent point of view.
Pauwels, W., Roodhooft, Filip
core