Results 81 to 90 of about 587,514 (266)
VOLATILITY AND WESTERN EUROPEAN PARTY SYSTEMS: TWO NEW APPROACHES
Baltic Journal of Political Science, 2015 The sharp rise in electoral volatility in the last two decades calls for a new explanation of Western European party systems. The established party system theory—Lipset and Rokkan’s “freezing hypothesis”—is not confirmed by today’s data.
Jan-Erik Lane
doaj +1 more source
Reforming state enterprises in socialist economies : guidelines for leasing them to entrepreneurs [PDF]
Since the state has proven to be incompetent in its management of state owned enterprises a new structure must be found that takes into account the incompetence of the state but ensures that the state's economic interests are preserved the best way ...
Schjelderup, Guttorm
core
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
On Social Identity, Subjective Expectations, and the Costs of Control [PDF]
Controlling employees can have severe consequences in situations that are not fully contractible. However, the perception of control may be contingent on the nature of the relationship between principal and agent. We, therefore, propose a principal-agent
Gerhard Riener, Simon Wiederhold
core
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Structural Estimation with a Randomized Trial of a Principal Agent Model of Medical Insurance with Moral Hazard [PDF]
Despite the importance of principal-agent models in the development of modern economic theory, there are few estimations of these models. We contribute to fill this gap in a field where moral hazard has traditionally been considered important: the ...
Vera-Hernandez, Marcos
core
Experience benefits and firm organization [PDF]
, 2012 A principal needs a worker for the production of a good. The worker can be hired as an internal agent, or an external agent under a contract. These two organizational modes correspond to in-house production and outsourcing, respectively.
Alger, Ingela +2 more
core +2 more sources
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Relationships between Institutional Economics of Cooperation and the Political Economy of Trust
Brazilian Political Science Review, 2008 The aim of this paper is to analyse the relationship between institutional economics of cooperation and the political economy of trust. Transactions costs, principal-agent theory, market power, increasing-returns theory and value creation, strategic ...
José Hernandéz
doaj