Results 91 to 100 of about 243,902 (282)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

CIVIL LIABILITY OF PRINCIPAL FOR THE ACTS OF AGENT – A COMPARISON BETWEEN FRANCE AND MAURITIUS

open access: yesAnali Pravnog Fakulteta u Beogradu
Mauritian civil law is strongly influenced by French civil law, for historical reasons. Civil liability, tort and contractual law, is regulated in an almost same manner in the two countries.
Goran GEORGIJEVIĆ
doaj   +1 more source

Social control of public expenditures in a multilevel principal-agent approach

open access: yesBrazilian Journal of Political Economy, 2015
This study enhances the principal-agent model by incorporating a multilevel perspective and differences among agency situations. A theoretical discussion is developed using a proposed intersection of methodological focuses and a descriptive ...
VALDEMIR PIRES   +1 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

The Principal-Agent Matching Market [PDF]

open access: yes
We propose a model based on competitive markets in order to analyse an economy with several principals and agents. We model the principal-agent economy as a two-sided matching game and characterise the set of stable outcomes of this principal-agent ...
Kaniska Dam
core  

Adaptive Contract Design for Crowdsourcing Markets: Bandit Algorithms for Repeated Principal-Agent Problems [PDF]

open access: yes, 2015
Crowdsourcing markets have emerged as a popular platform for matching available workers with tasks to complete. The payment for a particular task is typically set by the task's requester, and may be adjusted based on the quality of the completed work ...
Ho, Chien-Ju   +2 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

LIMITED DELEGATION AND FIRM CONTROL: A PRINCIPAL-AGENT ACCOUNT OF SOUTHERN AFRICAN DEVELOPMENT COMMUNITY (SADC) DECISION-MAKING ON ZIMBABWE’S LAND ISSUE

open access: yesJournal of International Studies, 2021
This paper accounts for Southern African Development Community (SADC) decision-making on Zimbabwe’s land issue from the year 2000 onwards. Guided by the principal-agent model, this paper argues that the delegation and control dynamics emerging from SADC’
Fungayi Promote Maraire   +2 more
doaj  

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