Results 91 to 100 of about 658,036 (304)
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
ASPECTS REGARDING INTERNATIONAL RESPONSIBILITY BY ANALYSING THE AGENCY RELATIONSHIP BETWEEN THE INTERNATIONAL ORGANIZATION AND THE STATE [PDF]
Challenges of the Knowledge Society, 2016 The study analyses the consequences for the responsibility of the organization and the relevant state of an agency relationship between an international organization acting as a principal and a state acting as its agent.
Ovidiu-Emilian IVĂNESCU
doaj
The Relevance of the Principal-Agent Model for the Analysis of Public Policies : Do the Objectives Conflict ? [PDF]
, 2007 This paper aims to provide empirical support for the use of the principal-agent framework in the analysis of public sector and public policies. After reviewing the different conditions to be met for a relevant analysis of the relationship between ...
Chatagny, F., Soguel, N.
core +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
The legal governance of the carbon market: challenges and application of private law in China
Carbon ManagementThe carbon market has gained widespread consensus as an important means to address the climate change. The legal system of the carbon market is the cornerstone of the stable operation, which currently relies on a top-down model promoted by the government.
Bo Chen, Kang Yuan, Xuwu Wen
doaj +1 more source
Too few cooks spoil the broth [PDF]
We consider a principal-agent relationship in which two tasks need to be carried out. Each task involves a decision. The principal can neither contract on the two decisions nor on the benefit which she receives from them but only on a signal, which ...
Marisa Ratto, Wendelin Schnedler
core
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Bargaining power and efficiency in insurance contracts [PDF]
Insurance contracts are frequently modelled as principal--agent relationships. Although it is commonly assumed that the principal, in this case the insurer, has complete freedom to design the contract, the problem formulation in much of the principal ...
John Quiggin, Robert G. Chambers
core
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
The Crowding-Out of Work Ethics [PDF]
This paper analyses optimal contracts in a principal-agent model where the agent is intrinsically motivated at the outset and there is an endogenous relationship between the structure of incentive payments and intrinsic motivation (crowding effects). The
Grepperud, Sverre +1 more
core