Results 91 to 100 of about 809,351 (338)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Structural Estimation with a Randomized Trial of a Principal Agent Model of Medical Insurance with Moral Hazard [PDF]

Despite the importance of principal-agent models in the development of modern economic theory, there are few estimations of these models. We contribute to fill this gap in a field where moral hazard has traditionally been considered important: the ...
Vera-Hernandez, Marcos
core  

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Are populist leaders playing the public? Examining the effect of populism on common and luxury good imports

Political Research Exchange
Populist movements have grown significantly around the world in recent years. Populist ideologies typically view social and political elites as the enemy of the people; however, populist leaders are themselves part of the elite class, and are politically
Brian Warby, Nicholas Bailey
doaj   +1 more source

Principal-Agent Problem with Minimum Performance Insurance [PDF]

A minimum performance insurance in the Principal-Agent problem is wealth reducing to the principal. This result points to further inefficiencies in mandatory individual Pension Funds' contracts, particularly the one established in the 1993's 100th Law in
Juan Manuel Julio
core  

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Relationships between Institutional Economics of Cooperation and the Political Economy of Trust

Brazilian Political Science Review, 2008
The aim of this paper is to analyse the relationship between institutional economics of cooperation and the political economy of trust. Transactions costs, principal-agent theory, market power, increasing-returns theory and value creation, strategic ...
José Hernandéz
doaj  

Incentive contract design for logistics enterprises to participate in online food safety regulation under government delegation: a study in the Chinese context

Cogent Food & Agriculture
Online food consumption growth has increased cross-regional food safety risks, highlighting gaps in traditional localized governance. Incorporating logistics enterprises into the regulatory framework is seen as a viable solution to the challenges of ...
Xiaoting Dai, Luping Wu, Linhai Wu
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

The Agency Theory Applied to the Investment Funds

BBR: Brazilian Business Review, 2004
This article seeks to verify the existence of a relationship between the rate of remuneration charged by the administrators of investment funds and the profitability of these portfolios, under the perspective of the Agency Theory. The Agency Theory seeks
Flávia Zóboli Dalmácio, Valcemiro Nossa   +1 more
doaj