Results 41 to 50 of about 587,585 (311)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Navigating Risk Aversion and Regret
International Journal of Financial StudiesThis study investigates the distinctive modeling of regret utility when compared with common utility. I also introduce the interplay between common utility and regret utility.
Miwaka Yamashita
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Political Decentralization and Governance in Hargaisa Local Government, Somaliland [PDF]
Applied Research in Administrative SciencesThis research aimed to reveal, through practical observation, the extent to which political decentralization can be considered a factor contributing to transparent governance in the local government of Hargaisa, Somaliland.
Mustafe Mahamoud, ABDILLAHI +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Risk distribution and benefit analysis of PPP projects based on public participation
International Journal of Strategic Property Management, 2020 This paper aims to formulate a new PPP project public-participation mechanism that uses “public satisfaction” as a direct influencing factor in conjunction with the public-private benefit model to achieve a substantial response from project stakeholders ...
Yinglin Wang, Ruolan Gao
doaj +1 more source
Moral Hazard in Dynamic Risk Management [PDF]
, 2015 We consider a contracting problem in which a principal hires an agent to manage a risky project. When the agent chooses volatility components of the output process and the principal observes the output continuously, the principal can compute the ...
Cvitanić, Jakša +2 more
core +5 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Principle – Agent Model for Sleeping Partnership Moral hazard [PDF]
Faslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2011 Game theory has a significant role in contemporary orthodox economics. This theory studies the strategic behavior of players. So strategic interaction is the key point in the games theory. Principalagent model is an application of the theory. This model
Mohammad Hadi Zahidi Vafa +1 more
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