Results 41 to 50 of about 8,580,386 (306)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Deterministic versus Stochastic Mechanisms in Principal–Agent Models [PDF]
, 2004 This paper shows that, contrary to what is generally believed, decreasing concavity of the agent’s utility function with respect to the screening variable is not sufficient to ensure that stochastic mechanisms are suboptimal.
Strausz, Roland
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Navigating Risk Aversion and Regret
International Journal of Financial StudiesThis study investigates the distinctive modeling of regret utility when compared with common utility. I also introduce the interplay between common utility and regret utility.
Miwaka Yamashita
doaj +1 more source
Buildings, 2022 Public–private partnerships (PPPs) are widely applied in the procurement of capital infrastructure, encompassing phases such as financing, design, construction, operation, and transfer.
Weiling Jiang +4 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Epistemics at Work: The Theory of Mind in Principal-Agent Relations [PDF]
SSRN Electronic Journal, 2014 Agency theory studies the impact of and remedies to asymmetrically distributed information in principal-agent relations. Yet, it does so in a surprisingly binary manner: it assumes the principal to be perfectly knowledgeable of some pieces of information (such as the agent’s risk aversion), while others (such as the agent’s true effort exerted) are ...
Linder, Stefan +2 more
openaire +6 more sources
Political Decentralization and Governance in Hargaisa Local Government, Somaliland [PDF]
Applied Research in Administrative SciencesThis research aimed to reveal, through practical observation, the extent to which political decentralization can be considered a factor contributing to transparent governance in the local government of Hargaisa, Somaliland.
Mustafe Mahamoud, ABDILLAHI +2 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Risk distribution and benefit analysis of PPP projects based on public participation
International Journal of Strategic Property Management, 2020 This paper aims to formulate a new PPP project public-participation mechanism that uses “public satisfaction” as a direct influencing factor in conjunction with the public-private benefit model to achieve a substantial response from project stakeholders ...
Yinglin Wang, Ruolan Gao
doaj +1 more source