Results 161 to 170 of about 173,695 (219)
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
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2023
Principal to Principal: Conversations in Servant Leadership, is an expanded edition of the original, published by Rowman and Littlefield in 2008. The book tells the story of a recently retired principal (John), who walks a first year principal (Linda) through her first year in serving a school.
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Principal to Principal: Conversations in Servant Leadership, is an expanded edition of the original, published by Rowman and Littlefield in 2008. The book tells the story of a recently retired principal (John), who walks a first year principal (Linda) through her first year in serving a school.
openaire +1 more source
Principal Components and Principal Clusters
Journal of Information and Optimization Sciences, 1987Abstract The use of principal components to reduce the number of dimensions so that graphieal representation of the data is possible has been developed. One. of the most important applications is the connexion with cluster analysis. It has not been defined the criteria by which to decide whether there is any justification for dividing a set of ...
Haruo Miyazaki, Youichi Seki
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From Principal Curves to Granular Principal Curves
IEEE Transactions on Cybernetics, 2014Principal curves arising as an essential construct in dimensionality reduction and data analysis have recently attracted much attention from theoretical as well as practical perspective. In many real-world situations, however, the efficiency of existing principal curves algorithms is often arguable, in particular when dealing with massive data owing to
Hongyun Zhang +3 more
openaire +2 more sources
The Principal: Still the Principal Teacher
NASSP Bulletin, 1972Exhorting his fellow principals to return to their original role as master teachers, the writer describes how the principal can create a school environment where learning is inquiry-oriented and students are persons.
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