Results 101 to 110 of about 2,390,711 (295)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Connections on the infinite dimensional path bundle of finite dimensional principal fiber bundles [PDF]
, 2012 Diese Arbeit beschreibt die Konstruktion des sogenannten Pfadbündels und basiert auf "Ronald O. Fulp: Connections on the path bundle of a principal fiber bundle" und "Andreas Kriegl and Peter W.
Fritz, Kurt
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Lagrangian Densities Invariant Under The Full . . .
, 1993 . First order Lagrangian densities on the bundle of connections of a principal bundle invariant under the full Lie algebra of the infinitesimal automorphisms of the principal bundle are classified. Keywords.
Automorphisms Of +3 more
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Connections and Higgs fields on a principal bundle
, 2008 Let M be a compact connected Kahler manifold and G a connected linear algebraic group defined over . A Higgs field on a holomorphic principal G-bundle εG over M is a holomorphic section θ of ad(εG)⊗Ω1M such that θ∧ ...
Biswas, Indranil, Gomez, Tomas L.
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Bundles over Quantum RealWeighted Projective Spaces
Axioms, 2012 The algebraic approach to bundles in non-commutative geometry and the definition of quantum real weighted projective spaces are reviewed. Principal U(1)-bundles over quantum real weighted projective spaces are constructed.
Tomasz Brzeziński, Simon A. Fairfax
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source