Results 111 to 120 of about 193,300 (324)

Bundles over Quantum RealWeighted Projective Spaces

open access: yesAxioms, 2012
The algebraic approach to bundles in non-commutative geometry and the definition of quantum real weighted projective spaces are reviewed. Principal U(1)-bundles over quantum real weighted projective spaces are constructed.
Tomasz Brzeziński, Simon A. Fairfax
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

The Atiyah bundle and connections on a principal bundle

open access: yesProceedings - Mathematical Sciences, 2010
Let M be a C∞ manifold and G a Lie a group. Let EG be a C∞ principal G-bundle over M. There is a fiber bundle C(EG) over M whose smooth sections correspond to the connections on EG. The pull back of EG to C(EG) has a tautological connection. We investigate the curvature of this tautological connection.
openaire   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Criterion for connections on principal bundles over a pointed Riemann surface

open access: yesComplex Manifolds, 2017
We investigate connections, and more generally logarithmic connections, on holomorphic principal bundles over a compact connected Riemann surface.
Biswas Indranil
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

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