Results 81 to 90 of about 226,801 (347)

Induced connections of two types on a surface of an affine space

open access: yesДифференциальная геометрия многообразий фигур, 2019
In the affine space the fundamental-group connection in the bundle associated with a surface as a manifold of tangent planes is investigated. The principal bundle contains a quotient bundle of tangent frames, the typical fiber of which is a linear group ...
A. Shults
doaj   +1 more source

Exotic spheres’ metrics and solutions via Kaluza-Klein techniques

open access: yesJournal of High Energy Physics, 2023
By applying an inverse Kaluza-Klein procedure, we provide explicit coordinate expressions for Riemannian metrics on two homeomorphic but not diffeomorphic spheres in seven dimensions.
T. Schettini Gherardini
doaj   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Сurvature-torsion tensor for Cartan connection

open access: yesДифференциальная геометрия многообразий фигур, 2019
A Lie group containing a subgroup is considered. Such a group is a principal bundle, a typical fiber of this principal bundle is the subgroup and a base is a homogeneous space, which is obtained by factoring the group by the subgroup.
Yu. Shevchenko
doaj   +1 more source

Principal bundle groupoids, their gauge group and their nerve [PDF]

open access: yesarXiv, 2021
We consider groupoids in the category of principal bundles, which we call principal bundles (PB) groupoids. Inspired by work by Th. Nikolaus and K. Waldorf, we generalise bundle gerbes over manifolds to bundle gerbes over groupoids and discuss a functorial correspondence between PB groupoids and bundle gerbes over groupoids.
arxiv  

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

An Approach to Classical Quantum Field Theory Based on the Geometry of Locally Conformally Flat Space-Time

open access: yesAdvances in Mathematical Physics, 2017
This paper gives an introduction to certain classical physical theories described in the context of locally Minkowskian causal structures (LMCSs). For simplicity of exposition we consider LMCSs which have locally Euclidean topology (i.e., are manifolds ...
John Mashford
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

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