Results 121 to 130 of about 2,362,828 (289)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Differential Cohomology and Gerbes: An Introduction to Higher Differential Geometry

Axioms
Differential cohomology is a topic that has been attracting considerable interest. Many interesting applications in mathematics and physics have been known, including the description of WZW terms, string structures, the study of conformal immersions, and
Byungdo Park
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

G2-metrics arising from non-integrable special Lagrangian fibrations

Complex Manifolds, 2019
We study special Lagrangian fibrations of SU(3)-manifolds, not necessarily torsion-free. In the case where the fiber is a unimodular Lie group G, we decompose such SU(3)-structures into triples of solder 1-forms, connection 1-forms and equivariant 3 × 3 ...
Chihara Ryohei
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Connections on noncommutative principal bundles [PDF]

In modern mathematical physics, one is often times concerned with the equations of motion of a certain class of physically representative objects. In field theory over a curved spacetime, these typically take the form of some certain systems of PDEs ...
Ryan Uhl, Lillian
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Characteristic principal bundles

, 1975
Characteristic principal bundles are the duals of commutative twisted group algebras. A principal bundle with locally compact second countable (Abelian) group and base space is characteristic iff it supports a continuous eigenfunction for almost every ...
Harvey A. Smith
core   +1 more source

Complex hidden symmetries in real spacetime and their algebraic structures

Nuclear Physics B
Considering real spacetime as a Lorentzian fiber in a complex manifold, there is a mismatch of the elementary linear representations of their symmetry groups, the real and complex Poincaré groups.
R. Vilela Mendes
doaj   +1 more source