Results 71 to 80 of about 2,362,828 (289)
Advances in Mathematical Physics, 2017 This paper gives an introduction to certain classical physical theories described in the context of locally Minkowskian causal structures (LMCSs). For simplicity of exposition we consider LMCSs which have locally Euclidean topology (i.e., are manifolds ...
John Mashford
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Semistable and numerically effective principal (Higgs) bundles [PDF]
, 2010 We study Miyaoka-type semistability criteria for principal Higgs G-bundles E on complex projective manifolds of any dimension. We prove that E has the property of being semistable after pullback to any projective curve if and only if certain line bundles,
Bruzzo, Ugo +5 more
core +1 more source
Principal 2-groupoid bundles with adjusted connections [PDF]
We develop a radically new theory of higher principal bundles with adjusted connections, avoiding the fake flatness condition. The theory can be realised in any model of higher Lie groupoids, such as higher (geometric) stacks.
Jalali Farahani, Mehran
core +5 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
On the Existence of Equivariant Embeddings of Principal Bundles into Vector Bundles [PDF]
Proceedings of the American Mathematical Society, 1983 Let G G be a finite group and let
Hansen, Vagn Lundsgaard +1 more
openaire +2 more sources
Principal spin-bundles and triality [PDF]
, 2015 In this paper we construct a family of spin Lie groups G with an outer automorphism of order three (triality automorphism) and we describe the subgroups of fixed points for this kind of automorphisms.
Sancho, Alvaro Antón
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source