Results 81 to 90 of about 2,362,828 (289)
Research article abstracts, the second most-read part of research papers after titles, generally follow disciplinary conventions, which are often manifested in their language use.
Motoko Asano +2 more
doaj +1 more source
Geometry of quantum principal bundles I [PDF]
A general non-commutative-geometric theory of principal bundles is developed. Quantum groups play the role of structure groups and general quantum spaces play the role of base manifolds. A general conceptual framework for the study of differential structures on quantum principal bundles is presented.
openaire +4 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Supersymmetric Yang-Mills theory as higher Chern-Simons theory
We observe that the string field theory actions for the topological sigma models describe higher or categorified Chern-Simons theories. These theories yield dynamical equations for connective structures on higher principal bundles.
Christian Sämann, Martin Wolf
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Picard Group and Fundamental Group of the Moduli of Higgs Bundles on Curves
Let X be an irreducible smooth projective curve of genus g ≥ 2 over ℂ. Let MG, Higgsδbe a connected reductive affine algebraic group over ℂ. Let Higgs be the moduli space of semistable principal G-Higgs bundles on X of topological type δ∈π1(G).
Chakraborty Sujoy, Paul Arjun
doaj +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
The geometric properties of reduced canonically symplectic spaces with symmetry, their relationship with structures on associated principal fiber bundles and some applications. Part 1 [PDF]
The canonical reduction method on canonically symplectic manifolds is analized in detail, the relationships with the geometric properties of associated principal fiber bundles endowed with connection structures are stated.
Yarema A. Prykarpatsky +2 more
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