Results 171 to 180 of about 2,261,156 (339)

A Novel Soil Profile Feature Reduction Model using Principal Component Analysis

, 2015
D. Ashok Kumar
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Robust Principal Component Analysis Based On Maximum Correntropy Power\n Iterations [PDF]

, 2019
Jean P. Chereau, Bruno Scalzo Dees, Danilo P. Mandic   +2 more
openalex   +1 more source

Tensor Robust Principal Component Analysis with Affine Transformation and the L2,1norms: Exact Low Rank Subspace Recovery and Outliers Detection in the Three Waylow-Rank Tensors in Big Data

, 2022
Habte Tadesse Likassa, Xian Wei
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Assessment of soil quality in arid zones using principal component analysis and GIS-based modeling. [PDF]

PLoS One
Shokr MS, Jalhoum MEM, Sayed ASA, Saeed M, Rebouh NY, Mohamed ES, Yousif IAH, Abdelhameed HH.   +7 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Multivariate Patterns in Mental Health Burden and Psychiatric Resource Allocation in Europe: A Principal Component Analysis. [PDF]

Healthcare (Basel)
Țîbîrnă A, Iliuta FP, Manea MC, Manea M.   +3 more
europepmc   +1 more source

Principal component analysis as an efficient method for capturing multivariate brain signatures of complex disorders—ENIGMA study in people with bipolar disorders and obesity

Sean R. McWhinney, Jaroslav Hlinka, Eduard Bakštein, Lorielle M. F. Dietze, Emily L. V. Corkum, Christoph Abé, Martin Alda, Nina Alexander, Francesco Benedetti, Michael Berk, Erlend Bøen, Linda M. Bonnekoh, Birgitte Boye, Katharina Brosch, Erick J. Canales‐Rodríguez, Dara M. Cannon, Udo Dannlowski, Caroline Demro, Ana M. Díaz‐Zuluaga, Torbjørn Elvsåshagen, Lisa T. Eyler, Lydia Fortea, Janice M. Fullerton, Janik Goltermann, Ian H. Gotlib, Dominik Grotegerd, Bartholomeus C. M. Haarman, Tim Hahn, Fleur M. Howells, Hamidreza Jamalabadi, Andreas Jansen, Tilo Kircher, Anna Luisa Klahn, Rayus Kuplicki, Elijah Lahud, Mikael Landén, Elisabeth J. Leehr, Carlos López‐Jaramillo, Scott Mackey, Ulrik Fredrik Malt, Fiona M. Martyn, Elena Mazza, Colm McDonald, Genevieve McPhilemy, Sandra Meier, Susanne Meinert, Elisa Melloni, Philip B. Mitchell, Leila Nabulsi, Igor Nenadić, Robert Nitsch, Nils Opel, Roel A. Ophoff, María Ortuño, Bronwyn J. Overs, Julian A. Pineda‐Zapata, Edith Pomarol‐Clotet, Joaquim Raduà, Jonathan Repple, Gloria Roberts, Elena Rodríguez‐Cano, Matthew D. Sacchet, Raymond Salvador, Jonathan Savitz, Freda Scheffler, Peter R. Schofield, Navid Schürmeyer, Chen Shen, Kang Sim, Scott R. Sponheim, Dan J. Stein, Frederike Stein, Benjamin Straube, Chao Suo, Henk Temmingh, Lea Teutenberg, Florian Thomas‐Odenthal, Sophia I. Thomopoulos, Snežana Urošević, Paula Usemann, Neeltje E.M. van Haren, Cristian Vargas, Eduard Vieta, Enric Vilajosana, Annabel Vreeker, Nils R. Winter, Lakshmi N. Yatham, Paul M. Thompson, Ole A. Andreassen, Christopher R. K. Ching, Tomáš Hájek   +90 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source