Results 71 to 80 of about 2,300,147 (337)

Optimisation of on-line principal component analysis

, 1998
Different techniques, used to optimise on-line principal component analysis, are investigated by methods of statistical mechanics. These include local and global optimisation of node-dependent learning-rates which are shown to be very efficient in ...
Biehl M, Biehl M, Biehl M, Bishop C, D Saad, E Schlösser, Hertz J, Kinouchi O, M Biehl, Rattray M, Saad D, Sanger T   +11 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Probabilistic principal component analysis for metabolomic data

BMC Bioinformatics, 2010
Background Data from metabolomic studies are typically complex and high-dimensional. Principal component analysis (PCA) is currently the most widely used statistical technique for analyzing metabolomic data. However, PCA is limited by the fact that it is
Brennan Lorraine, Nyamundanda Gift, Gormley Isobel   +2 more
doaj   +1 more source

Principal Component Analysis of Weak Lensing Surveys

, 2005
We study degeneracies between cosmological parameters and measurement errors from cosmic shear surveys using a principal component analysis of the Fisher matrix.
Anderson, Bacon, Bacon, Bacon, Bartelmann, Brainerd, Brown, Colless, Contaldi, D. Munshi, Efstathiou, Efstathiou, Groch, Hamilton, Hamilton, Heavens, Hoekstra, Hoekstra, Hu, Hu, Huterer, Huterer, Hämmerle, Ishak, Jarvis, Kaiser, Kaiser, Kaiser, Kilbinger, Kilbinger, Kilbinger, M. Kilbinger, Maoli, Massey, Mastsubara, Mellier, Peacock, Rhodes, Rocha, Réfrégier, Réfrégier, Schneider, Schneider, Schneider, Schneider, Seljak, Spergel, Tegmark, Tegmark, Tereno, van Waerbeke, van Waerbeke, van Waerbeke, Vogeley, Wang, Wittman   +55 more
core   +4 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Quantum image classification using principal component analysis

, 2015
We present a novel quantum algorithm for classification of images. The algorithm is constructed using principal component analysis and von Neuman quantum measurements.
Gawron, Piotr, Ostaszewski, Mateusz, Sadowski, Przemysław   +2 more
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Regularized Principal Component Analysis for Spatial Data

, 2016
In many atmospheric and earth sciences, it is of interest to identify dominant spatial patterns of variation based on data observed at $p$ locations and $n$ time points with the possibility that $p>n$. While principal component analysis (PCA) is commonly
Huang, Hsin-Cheng, Wang, Wen-Ting
core   +2 more sources