Results 51 to 60 of about 265,281 (248)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Principal component analysis for three-dimensional structured illumination microscopy (PCA-3DSIM)

Light: Science & Applications
Three-dimensional structured illumination microscopy (3DSIM) is an essential super-resolution imaging technique for visualizing volumetric subcellular structures at the nanoscale, capable of doubling both lateral and axial resolution beyond the ...
Jiaming Qian, Weiyi Xia, Yuxia Huang, Jing Feng, Qian Chen, Chao Zuo   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Principal Component Analysis (PCA) in the Context of Radar Polarimetry [PDF]

PIERS Online, 2007
Statistical and computational techniques for revealing the internal structure that underlies the set of random correlated data exists in a great variety at present; and target decomposition theorems, either in the coherent or incoherent formulation, are well established.
Boerner, Wolfgang-Martin, Lüneburg, Ernst, Danklmayer, Andreas   +2 more
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Principal Components Analysis for the Interpretation of Humidification Phenomena—Preliminary Results

Proceedings, 2019
Moisture is one of the major causes of building decay, compromising the indoor air quality and the durability of building components. Infrared thermography is a non-destructive technique that can be used to prevent damage caused by the presence of water.
Eva Barreira, Maria Lurdes Simões, Ricardo M. S. F. Almeida, Sofia Pinto   +3 more
doaj   +1 more source

Kombinasi Feature Selection Fisher Score dan Principal Component Analysis (PCA) untuk Klasifikasi Cervix Dysplasia

Jurnal Teknologi Informasi dan Ilmu Komputer, 2020
Pengamatan citra Pap Smear merupakan langkah yang sangat penting dalam mendiagnosis awal terhadap gangguan servik. Pengamatan tersebut membutuhkan sumber daya yang besar. Dalam hal ini machine learning dapat mengatasi masalah tersebut.
Krisan Aprian Widagdo, Kusworo Adi, Rahmat Gernowo   +2 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

OPTIMALISASI HASIL PROSES WIRE-CUT EDM DENGAN METODE PRINCIPAL COMPONENT ANALYSIS (PCA)

Rotor: Jurnal Ilmiah Teknik Mesin, 2017
Some of the desired performance of the machining process Wire-Cut Electric Discharge Machining CV. Catur Prasetya Packindo is rate workmanship short and surface roughness of lower cutting. The problem is how to manage the performance of process variables
Mulyadi Mulyadi, Agus Puji Suryanto
doaj