Results 181 to 190 of about 5,566,031 (259)

Bayesian multivariate sparse functional principal components analysis with application to longitudinal microbiome multiomics data. [PDF]

Ann Appl Stat, 2022
Jiang L, Elrod C, Kim JJ, Swafford AD, Knight R, Thompson WK.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Contrastive Functional Principal Components Analysis. [PDF]

Proc AAAI Conf Artif Intell
Zhang E, Li D.
europepmc   +1 more source

A practical introduction to EEG Time-Frequency Principal Components Analysis (TF-PCA). [PDF]

Dev Cogn Neurosci, 2022
Buzzell GA, Niu Y, Aviyente S, Bernat E.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population. [PDF]

Alzheimers Dement
Willett JDS, Waqas M, Naumenko S, Mullin K, Hecker J, Bertram L, Lange C, Vlachos I, Hide W, Tanzi RE, Prokopenko D.   +10 more
europepmc   +1 more source

An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape. [PDF]

J Imaging, 2022
Farnell DJJ.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Principal Components for Practice-Oriented Measurement of Running Technique: A Proof-Of-Concept Study. [PDF]

Eur J Sport Sci
Debertin D, Kiebacher J, Zhang M, Federolf P.   +3 more
europepmc   +1 more source

Detecting gene-gene interactions from GWAS using diffusion kernel principal components. [PDF]

BMC Bioinformatics, 2022
Walakira A, Ocira J, Duroux D, Fouladi R, Moškon M, Rozman D, Van Steen K.   +6 more
europepmc   +1 more source