Results 211 to 220 of about 2,337,506 (337)

Covariate-adjusted hybrid principal components analysis for region-referenced functional EEG data. [PDF]

open access: yesStat Interface, 2022
Scheffler AW   +4 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Exploring body composition and physical condition profiles in relation to playing time in professional soccer: a principal components analysis and Gradient Boosting approach. [PDF]

open access: yesFront Physiol
Ulloa-Díaz D   +7 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Improving racial data equity among minority groups in South Carolina using COVID-19 as an example: application of principal components analysis. [PDF]

open access: yesPopul Health Metr
Rubaiya F   +9 more
europepmc   +1 more source

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