Results 211 to 220 of about 2,294,043 (337)

mbDenoise: microbiome data denoising using zero-inflated probabilistic principal components analysis. [PDF]

Genome Biol, 2022
Zeng Y, Li J, Wei C, Zhao H, Wang T.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Principal components of type 2 diabetes risk: an exploratory factor analysis in an Iranian cohort. [PDF]

BMC Public Health
Geravandi S, Emamgholipour S, Pakdaman M, Sari AA, Esmaeili A.   +4 more
europepmc   +1 more source

Increased signal-to-noise ratios within experimental field trials by regressing spatially distributed soil properties as principal components. [PDF]

Elife, 2022
Berry JC, Qi M, Sonawane BV, Sheflin A, Cousins A, Prenni J, Schachtman DP, Liu P, Bart RS.   +8 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Hierarchical relations among principal component and factor analysis procedures elucidated from a comprehensive model [PDF]

Kohei Adachi
openalex   +1 more source

Tensor Robust Principal Component Analysis with Affine Transformation and the L2,1norms: Exact Low Rank Subspace Recovery and Outliers Detection in the Three Waylow-Rank Tensors in Big Data

, 2022
Habte Tadesse Likassa, Xian Wei
openalex   +1 more source

Revealing Principal Components, Patterns, and Structural Gaps in Health Security among High-Income Countries: A Comparative Analysis Using PCA and a Multi-Scenario Clustering Approach. [PDF]

F1000Res
Nasser AA, Aljober MN, Alghawli ASA, Essayed AAK.   +3 more
europepmc   +1 more source

Intrafractional motion models based on principal components in Magnetic Resonance guided prostate radiotherapy. [PDF]

Phys Imaging Radiat Oncol, 2021
Fransson S, Tilly D, Ahnesjö A, Nyholm T, Strand R.   +4 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source