Results 221 to 230 of about 2,367,896 (336)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Exploring body composition and physical condition profiles in relation to playing time in professional soccer: a principal components analysis and Gradient Boosting approach. [PDF]

Front Physiol
Ulloa-Díaz D, Fábrica-Barrios G, Jorquera-Aguilera C, Guede-Rojas F, Pérez-Contreras J, Lozano-Jarque D, Carvajal-Parodi C, Romero-Vera L.   +7 more
europepmc   +1 more source

Kernel principal components based cascade forest towards disease identification with human microbiota. [PDF]

BMC Med Inform Decis Mak, 2021
Zhou J, Ye Y, Jiang J.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mineral Assemblages at IODP Sites U1387 and U1389, Gulf of Cadiz: Definition by Principal Component Analysis and Interpretation of Their Geologic Significance

, 2015
Jory Lombardi
openalex   +1 more source

Development of computational algorithms for daily water leak detection in district metered areas based on the principal component analysis

, 2021
Suwan Park, Jae-Hong Ha
openalex   +1 more source

Improving racial data equity among minority groups in South Carolina using COVID-19 as an example: application of principal components analysis. [PDF]

Popul Health Metr
Rubaiya F, O'Connor J, Kolev LN, Antill JM, Iiams M, Martin LA, Joseph CZ, Youngblood C, Almeda-Garrett J, Kelemen LE.   +9 more
europepmc   +1 more source

Principal Component [PDF]

, 2020
openaire   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Principal components of type 2 diabetes risk: an exploratory factor analysis in an Iranian cohort. [PDF]

BMC Public Health
Geravandi S, Emamgholipour S, Pakdaman M, Sari AA, Esmaeili A.   +4 more
europepmc   +1 more source