Results 151 to 160 of about 2,259,407 (341)

On the distribution of the largest eigenvalue in principal components analysis

, 2001
I. Johnstone
semanticscholar   +1 more source

A penalized matrix decomposition, with applications to sparse principal components and canonical correlation analysis.

Biostatistics, 2009
D. Witten, R. Tibshirani, T. Hastie
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Principal component analysis: a review and recent developments

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2016
I. Jolliffe, J. Cadima
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Genetic parameters and principal components analysis of breeding value for birth and weaning weight in Egyptian buffalo. [PDF]

Anim Biosci, 2021
Salem MMI, Amin AMS, Ashour AF, Ibrahim MME, Abo-Ismail MK.   +4 more
europepmc   +1 more source

Rotated Spectral Principal Component Analysis (rsPCA) for Identifying Dynamical Modes of Variability in Climate Systems [PDF]

, 2020
Clément Guilloteau, Antonios Mamalakis, Lawrence Vulis, Phong V. V. Le, Tryphon T. Georgiou, Efi Foufoula‐Georgiou   +5 more
openalex   +1 more source

A Topological Principal Component Analysis.

, 2020
Topological Principal Component Analysis (TPCA) is a multidimensional descriptive method witch studies a homogeneous set of continuous variables defined on the same set of individuals. Its a topological method of data analysis that consists of comparing and classifying proximity measures from among some of the most widely used measures for continuous ...
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Application of the principal component analysis to detect semantic differences during the content analysis of social networks

, 2018
Igor Rytsarev, D.D. Kozlov, Natalia Kravtsova, Alexander Kupriyanov, Konstantin Liseckiy, Sergey Liseckiy, Rustam Paringer, Natalya Samykina   +7 more
openalex   +1 more source