Results 191 to 200 of about 2,259,407 (341)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Constrained Multivariate Functional Principal Components Analysis for Novel Outcomes in Eye-Tracking Experiments. [PDF]

Stat Biosci
Kwan B, Sugar CA, Qian Q, Shic F, Naples A, Johnson SP, Webb SJ, Jeste S, Faja S, Levin AR, Dawson G, McPartland JC, Şentürk D.   +12 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A Principal Components Analysis and Functional Annotation of Differentially Expressed Genes in Brain Regions of Gray Rats Selected for Tame or Aggressive Behavior. [PDF]

Int J Mol Sci
Chadaeva I, Kozhemyakina R, Shikhevich S, Bogomolov A, Kondratyuk E, Oshchepkov D, Orlov YL, Markel AL.   +7 more
europepmc   +1 more source

Mapping Human Vulnerability to Extreme Heat: A Critical Assessment of Heat Vulnerability Indices Created Using Principal Components Analysis. [PDF]

Environ Health Perspect, 2020
Conlon KC, Mallen E, Gronlund CJ, Berrocal VJ, Larsen L, O'Neill MS.   +5 more
europepmc   +1 more source

An Application of Principal Component Analysis to The Study of Activated Sludge Treatment System Performance Efficiency For the Degradation of Malathion [PDF]

, 1999
Imran Hashmi, S. Shahid Sha, Moazzam Ali Khan, M. Altaf Khan   +3 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Using Principal Components Analysis and IDW Interpolation to Determine Spatial and Temporal Changes of Surface Water Quality of Xin'anjiang River in Huangshan, China. [PDF]

Int J Environ Res Public Health, 2020
Yang W, Zhao Y, Wang D, Wu H, Lin A, He L.   +5 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Principal Component Analysis of the Modified Clinical Test Ofsensory Interaction in Healthy Adult Humans

, 2020
Oseikhuemen Davis Ojie, Reza Saatchi
openalex   +1 more source