Results 31 to 40 of about 194,639 (254)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Animals, 2021 Cross-resistance occurs between antimicrobials with either similar mechanisms of action and/or similar chemical structures, or even between unrelated antimicrobials.
Daniel Nenene Qekwana +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Principal Component Analysis (PCA)-Supported Underfrequency Load Shedding Algorithm [PDF]
Energies, 2020 This research represents a conceptual shift in the process of introducing flexibility into power system frequency stability-related protection. The existing underfrequency load shedding (UFLS) solution, although robust and fast, has often proved to be incapable of adjusting to different operating conditions.
Tadej Skrjanc +2 more
openaire +3 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Comparison of projection of distance techniques for genetic diversity studies
Acta Scientiarum. Agronomy, 2019 The objective of this study was to compare different graphical dispersion analysis techniques in two- or three-dimensional planes. In this study, the data from different published works were used in order to determine the best methodology for analyzing ...
Isabela de Castro Sant'Anna +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Principal Component Analysis (PCA) in Ichnology
, 2021 I observed the ichnofabric variable on 600 ichnofabric units in the Samarinda area of Kutai Basin. Five ichnofabric variables are bioturbation index (BI), biodiversity (ID), number of behaviors (NB), penetration depth (PD), and burrow diameter (DM) that perform as a semi-quantitative form. It must process the data with principal component analysis (PCA)
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source