Results 51 to 60 of about 25,782,438 (282)

A Corrected Criterion for Selecting the Optimum Number of Principal Components

Austrian Journal of Statistics, 2016
Determining the optimum number of components to be retained is a key problem in principal component analysis (PCA). Besides the rule of thumb estimates there exist several sophisticated methods for automatically selecting the dimensionality of the data ...
Hannes Kazianka, Jürgen Pilz
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A Single Classifier Using Principal Components Vs Multi-Classifier System: In Landuse-LandCover Classification of WorldView-2 Sensor Data [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2014
In remote sensing community, Principal Component Analysis (PCA) is widely utilized for dimensionality reduction in order to deal with high spectral-dimension data. However, dimensionality reduction through PCA results in loss of some spectral information.
L .N. Eeti, K. M. Buddhiraju, A. Bhattacharya   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The Use of High-Resolution Satellite Imagery to Determine the Status of a Large-Scale Outbreak of Southern Pine Beetle

Remote Sensing
Timely detection of insect infestation (or other disturbance) in a forest is vital for an adequate response plan to be developed. To determine the status of an active infestation of southern pine beetle (Dendroctonus frontalis) in the Bienville National ...
Michael K. Crosby, T. Eric McConnell, Jason J. Holderieath, James R. Meeker, Chris A. Steiner, Brian L. Strom, Crawford (Wood) Johnson   +6 more
doaj   +1 more source

Exploring functional data analysis and wavelet principal component analysis on ecstasy (MDMA) wastewater data

BMC Medical Research Methodology, 2016
Background Wastewater-based epidemiology (WBE) is a novel approach in drug use epidemiology which aims to monitor the extent of use of various drugs in a community.
Stefania Salvatore, Jørgen G. Bramness, Jo Røislien   +2 more
doaj   +1 more source

Principal Component Analysis (PCA) in the Context of Radar Polarimetry [PDF]

PIERS Online, 2007
Statistical and computational techniques for revealing the internal structure that underlies the set of random correlated data exists in a great variety at present; and target decomposition theorems, either in the coherent or incoherent formulation, are well established.
Boerner, Wolfgang-Martin, Lüneburg, Ernst, Danklmayer, Andreas   +2 more
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source