Results 61 to 70 of about 408,145 (290)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The Use of High-Resolution Satellite Imagery to Determine the Status of a Large-Scale Outbreak of Southern Pine Beetle

Remote Sensing
Timely detection of insect infestation (or other disturbance) in a forest is vital for an adequate response plan to be developed. To determine the status of an active infestation of southern pine beetle (Dendroctonus frontalis) in the Bienville National ...
Michael K. Crosby, T. Eric McConnell, Jason J. Holderieath, James R. Meeker, Chris A. Steiner, Brian L. Strom, Crawford (Wood) Johnson   +6 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Exploring functional data analysis and wavelet principal component analysis on ecstasy (MDMA) wastewater data

BMC Medical Research Methodology, 2016
Background Wastewater-based epidemiology (WBE) is a novel approach in drug use epidemiology which aims to monitor the extent of use of various drugs in a community.
Stefania Salvatore, Jørgen G. Bramness, Jo Røislien   +2 more
doaj   +1 more source

Validation of nonlinear PCA

, 2012
Linear principal component analysis (PCA) can be extended to a nonlinear PCA by using artificial neural networks. But the benefit of curved components requires a careful control of the model complexity.
A Herman, A Ilin, AN Gorban, B Chalmond, B Christiansen, B Efron, B Schölkopf, BW Lu, D DeMers, JB Tenenbaum, LK Saul, M Scholz, MA Kramer, Matthias Scholz, MR Hestenes, ND Lawrence, P Demartines, R Hecht-Nielsen, S Girard, S Harmeling, S Mika, ST Roweis, T Hastie, T Kohonen, WW Hsieh, WW Hsieh, WW Hsieh   +26 more
core   +1 more source

Principal Component Analysis Of Synthetic Galaxy Spectra [PDF]

, 1998
We analyse synthetic galaxy spectra from the evolutionary models of Bruzual&Charlot and Fioc&Rocca-Volmerange using the method of Principal Component Analysis (PCA).
Alfonso Aragón-Salamanca, Bailer-Jones, Bromley, Bruzual, Bruzual, Bruzual, Colless, Connolly, Everson, Fioc, Folkes, Folkes, Francis, Fukugita, Galaz, Glazebrook, Gunn, Gunn, Kennicutt, Leitherer, Lejeune, Mathis, Murtagh, Ofer Lahav, Osterbrock, Scalo, Shai Ronen, Sodré, Tinsley, Worthey   +29 more
core   +3 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Fast, Exact Bootstrap Principal Component Analysis for p>1 million [PDF]

, 2014
Many have suggested a bootstrap procedure for estimating the sampling variability of principal component analysis (PCA) results. However, when the number of measurements per subject ($p$) is much larger than the number of subjects ($n$), the challenge of
Caffo, Brian, Fisher, Aaron, Schwartz, Brian, Zipunnikov, Vadim   +3 more
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source