Results 91 to 100 of about 6,258,593 (311)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

On the negative coupling O(N) model in 2d at high temperature

Journal of High Energy Physics
In this work, I consider N-component scalar quantum field theory in two dimensions interacting with an upside-down quartic potential. Working in the large N limit, the model can be solved non-perturbatively using the saddle-point method for sufficiently ...
Paul Romatschke
doaj   +1 more source

Prediction of Stress Increase at Ultimate in Unbonded Tendons Using Sparse Principal Component Analysis

International Journal of Concrete Structures and Materials, 2019
While internal and external unbonded tendons are widely utilized in concrete structures, an analytical solution for the increase in unbonded tendon stress at ultimate strength, $$\Delta f_{ps}$$ Δfps , is challenging due to the lack of bond between ...
Eric McKinney, Minwoo Chang, Marc Maguire, Yan Sun   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Sharing with a risk-neutral agent [PDF]

In the standard solution to the principal–agent problem, a risk-neutral agent bears all the risk. The author shows that, in fact, multiple solutions exist, and often the risk-neutral agent is not the sole bearer of risk. As risk aversion approaches zero,
Joseph G. Haubrich
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Generalized power method for sparse principal component analysis [PDF]

In this paper we develop a new approach to sparse principal component analysis (sparse PCA). We propose two single-unit and two block optimization formulations of the sparse PCA problem, aimed at extracting a single sparse dominant principal component of
Journée, Michel, Nesterov, Yurii, Richtarik, Peter, Sepulchre, Rodolphe   +3 more
core  

Regresion PLS y PCA como Solucion al Problema de Multicolinealidad en Regresion Multiple

Revista de Matemática: Teoría y Aplicaciones, 2011
We present and compare principal components regression and partial least squares regression, and their solution to the problem of multicollinearity. We illustrate the use of both techniques, and demonstrate the superiority of partial least squares.
José Carlos Vega Vilca, Josué Guzman
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source