Results 61 to 70 of about 1,100,085 (268)
Phosphoinositides and inositol phosphates as molecular glues
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
The Principles of Interpretability
A generalized Veltman semantics developed by de Jongh is used to investigate correspondences between several extensions of interpretability logic, IL. In this paper we present some new results on independences.
openaire +5 more sources
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Non-discrimination in the draft of the Serbian Civil Code [PDF]
The draft of the Serbian Civil Code facilitates the combat against discrimination in several ways. It enables the impact of non-discrimination norms in the civil law relations according to each of three theoretical models of appllication od human rights ...
Rašević Živorad M.
doaj
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
I live with the feeling that, in the past few years, Romania has been a drifting ship. We do not know where is it going, nor the place it will arrive at.
Elena ANGHEL
doaj
Kur’an, indirildiği toplumun kullandığı iletişim dilini esas alan bir hitap tarzına sahip ilâhî vahiydir. Bu yüzden ilk muhataplar gelen vahyin dilini çoğunlukla anlamışlardır.
Yahya Karataş
doaj
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
PUBLIC ADMINISTRATION TOOL DEVELOPMENT: PROBLEMS, PROSPECTS
The need to transform the present Russian economics public administration mechanism relates to changes in the public administration’s object and subject as well as with the aims and tasks of rendering public services.
G. G. Kouznetsova
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source

