Results 21 to 30 of about 208,179 (267)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Double Traveling Salesman Problem with Multiple Stacks and a Choice of Container Types
Mathematics, 2020 The double traveling salesman problem with multiple stacks involves the transportation of goods between two regions. In one region, a vehicle carrying a container visits customers, where pallets of goods are loaded into the container.
Lars Magnus Hvattum +2 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
The Disobeying 'Soldier': Use of an Achiral Group to Modulate Chiral Induction in PNA Duplexes
CHIMIA, 2018 Peptide nucleic acid (PNA) is a synthetic analogue of DNA in which the natural nucleobases A, G, C, and T are linked to an achiral, charge neutral, pseudopeptide backbone.
Artur Sargun +2 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Journal of Moral Theology, 2017 If not considered an isolated principle but as part of Catholic moral theology, the principle of double can serve as an aid to discernment of the morality of an action, as one moral principle in the context of a broader moral system.
Gina Maria Noia
doaj
Advances in Civil Engineering, 2019 The stress-strain relationship of frozen soil is a hot research topic in the field of frozen soil mechanics. In order to study the effect of particle crushing on the stress-strain relationship, a series of triaxial compression tests for frozen sandy soil
Junlin He +4 more
doaj +1 more source