Results 31 to 40 of about 208,179 (267)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Medisan, 2012 Entre los 5 principios éticos en medicina paliativa, el del doble efecto o de razonamiento práctico no solo sirve para determinar la licitud o ilicitud de una acción y puede producir 2 efectos: uno bueno y otro malo, sino que es posible aplicarlo en los ...
Ricardo Hodelín Tablada
doaj
IEEE Access, 2019 Overhead cranes with double-pendulum effect seem more practical than those with single-pendulum effect. However, in this case, the dynamic performance analysis and the controller design become more difficult.
Huimin Ouyang +4 more
doaj +1 more source
Micromachines, 2022 Due to the influence of nonlinear loads, power quality control devices under the traditional double closed-loop control strategy suffer from a large output voltage harmonic distortion rate and a slow harmonic suppression response and cannot meet the high-
Chengkuan Wan +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Double Acceptor Interaction in Semimagnetic Quantum Dot [PDF]
Журнал нано- та електронної фізики, 2011 The effect of geometry of the semimagnetic Quantum Dot on the Interaction energy of a double acceptor is computed in the effective mass approximation using the variational principle.
A. Merwyn Jasper D. Reuben, K. Jayakumar
doaj
The Principle of Double Effect and Proportionate Reason
AMA Journal of Ethics, 2007 Health care providers can apply the principle of double effect and proportionate reasoning to assess whether or not some medical treatments are morally justifiable. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source