Results 31 to 40 of about 173,789,655 (294)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Disobeying 'Soldier': Use of an Achiral Group to Modulate Chiral Induction in PNA Duplexes
CHIMIA, 2018 Peptide nucleic acid (PNA) is a synthetic analogue of DNA in which the natural nucleobases A, G, C, and T are linked to an achiral, charge neutral, pseudopeptide backbone.
Artur Sargun +2 more
doaj +1 more source
The Double Traveling Salesman Problem with Multiple Stacks and a Choice of Container Types
Mathematics, 2020 The double traveling salesman problem with multiple stacks involves the transportation of goods between two regions. In one region, a vehicle carrying a container visits customers, where pallets of goods are loaded into the container.
Lars Magnus Hvattum +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 1991 Joseph Boyle raises important questions about the place of the double-effect exception in absolutist moral theories. His own absolutist theory (held by many, but not all, Catholic moralists), which derives from the principles that fundamental human ...
Donagan, Alan
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Medisan, 2012 Entre los 5 principios éticos en medicina paliativa, el del doble efecto o de razonamiento práctico no solo sirve para determinar la licitud o ilicitud de una acción y puede producir 2 efectos: uno bueno y otro malo, sino que es posible aplicarlo en los ...
Ricardo Hodelín Tablada
doaj
Advances in Civil Engineering, 2019 The stress-strain relationship of frozen soil is a hot research topic in the field of frozen soil mechanics. In order to study the effect of particle crushing on the stress-strain relationship, a series of triaxial compression tests for frozen sandy soil
Junlin He +4 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source