Results 31 to 40 of about 173,210 (296)
Plato on the Mechanics of Koinōnia Formation
Areté, 2022 This paper argues that, in order to understand the unified relations that are commonly predicated of koinōnia in the ethical, political, and cosmological spheres respectively, one must first appreciate certain prerequisite “principles” or “rules” that ...
Stephanos Stephanides
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Правоприменение, 2021 The subject of the research is the principle of proportionality as an intersectoral principle of legal responsibility. It has a constitutional nature and guarantees fairness in resolving the cases of constitutional responsibility. This principle provides
V. V. Ignatenko +2 more
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The principle of proportionality and tax limitations of EU fundamental freedoms [PDF]
, 2015 Integracja europejska obejmuje wiele obszarów społeczno-gospodarczych, a jednym z nich są systemy podatkowe państw członkowskich. Harmonizacji poddano podatki pośrednie, natomiast podatki bezpośrednie pozostają nadal domeną państw członkowskich ...
Lipniewicz, Rafał
core +2 more sources
Regulation of InsurTech: Is the Principle of Proportionality an Answer?
Risks, 2021 In the view of the current discussion on how to regulate the emerging InsurTech companies, if at all, the author attempts to demonstrate that rather than automatically introducing new regulation, the principle of proportionality can, in most cases, help ...
Marta Ostrowska
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Piecewise straightening and Lipschitz simplicial volume [PDF]
, 2015 We study the Lipschitz simplicial volume, which is a metric version of the simplicial volume. We introduce the piecewise straightening procedure for singular chains, which allows us to generalize the proportionality principle and the product inequality ...
Strzałkowski, Karol
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Measure homology and singular homology are isometrically isomorphic [PDF]
, 2005 Measure homology is a variation of singular homology designed by Thurston in his discussion of simplicial volume. Zastrow and Hansen showed independently that singular homology (with real coefficients) and measure homology coincide algebraically on the ...
Loeh, Clara
core +3 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source